#VisualAbstract: Anti-tau antibody Semorinemab not shown to slow clinical progression of Alzheimer’s disease
1. In this randomized controlled trial, among 457 participants with prodromal to mild Alzheimer’s disease, semorinemab was not shown to ...
Tag: Alzheimer’s disease
Anti-tau antibody Semorinemab not shown to slow clinical progression of Alzheimer’s disease
1. In this randomized controlled trial, among 457 participants with prodromal to mild Alzheimer’s disease, semorinemab was not shown to ...
Rare APOE missense variants V236E and R251G associated with substantial reduction in risk of Alzheimer disease
1. APOE ε3 (V236E) and APOE ε4 (R251G), 2 rare missense genetic variants, both had a substantial association with reducing ...
Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
1. This systematic review and meta-analysis demonstrated that the onset of Alzheimer disease in people with Down syndrome is as ...
Early onset Lewy Body Dementia is more clinically distinct from Alzheimer Dementia than late onset Lewy Body Dementia
1. Select features distinguish early-onset Lewy Body Dementia from early-onset Alzheimer dementia, including: hallucinations, slowness, apathy and motor deterioration. 2. ...
#VisualAbstract: Increased physical activity is a long-term protective factor for dementia
1. Physical activity was significantly associated with a decreased incidence of all-cause dementia and Alzheimer’s disease, irrespective of follow-up length, ...
Familial natural short sleep mutations may reduce Alzheimer’s Disease pathology in mice [PreClinical]
1. Certain sleep phenotypes, such as those with the familial natural short sleepers (FNSS) mutation, anecdotally do not exhibit the ...
Initiation of targeted disease-modifying antirheumatic drugs in patients with rheumatoid arthritis not associated with reduced risk of Alzheimer disease and related dementia
1. There were no differences in the risk of Alzheimer disease and related dementia in patients with rheumatoid arthritis treated ...
Subcortical neurons associated with sleep disturbances in neurodegenerative disease
1. Greater number of neurons in the lateral hypothalamic area (LHA) and tuberomammillary nucleus (TMN) were correlated with decreased sleep ...
Mirtazapine not effective in treating agitation in patients with dementia
1. Compared to placebo, mirtazapine did not significantly reduce agitation in patients with dementia. 2. There was no significant difference ...
