Tag: Alzheimer’s disease

1. Older patients presenting to the dentist with missing teeth were more likely to have Alzheimer’s Disease. Evidence Rating Level: 2 (Good) The association between cognitive impairment and worse oral health is well-established: In particular, individuals with cognitive impairment are at greater risk for having missing teeth, cavities, plaque accumulation, and...
1. Systematic review found that social prescribing was associated with a reduction in depressive symptoms in patients with dementia without a diagnosis of major depressive disorder. 2. Non-drug interventions either alone or in combination with drug interventions may be the most efficacious intervention for these patients. Evidence Rating Level: 1 (Excellent) Study...
1. Intensive treatment of blood pressure resulted in small but statistically significant greater decline in hippocampal volume compared to standard treatment. 2. No significant differences between treatment groups in other Alzheimer’s disease biomarkers. Evidence Rating Level: 2 (Good) Several randomized clinical trials have suggested that control of hypertension reduces future risk of...
1. Donanemab resulted in a modestly better composite score for cognition and the ability to perform activities of daily living in patients with early Alzheimer’s disease compared to placebo. 2. Treatment with donanemab resulted in amyloid-related imaging abnormalities. Evidence Rating Level: 1 (Excellent) Study Rundown: Buildup of amyloid-β (Aβ) peptide in amyloid...
1. Increases in tau phosphorylated at threonine 181 (p-tau181) in blood plasma were associated with progressive, longitudinal neurodegeneration. 2. Findings of p-tau181 were consistent with brain regions characteristic of Alzheimer’s disease, though only among participants with elevated brain amyloid-β. Evidence Rating Level: 2 (Good) Alzheimer’s disease (AD) is the leading form of...
1. Single Medicare beneficiaries with Alzheimer’s disease and related dementias (ADRD) were more likely to make late credit account payments and develop suboptimal credit scores compared to those without ADRD. 2. Adverse financial events among those with ADRD occurred as early as six months prior to diagnosis, worsening over time...
1. Causes of death reported on death certificates drastically underestimated dementia mortality burden by a factor of 2.7. 2. Non-Hispanic Black persons demonstrated significantly greater mortality burden than non-Hispanic White persons. Evidence Rating Level: 2 (Good) Dementia is a leading cause of death in the US and abroad, with Alzheimer’s disease accounting...
1. Delirium was significantly associated with long-term cognitive decline. 2. Across all studies, delirium groups demonstrated worse cognitive outcomes than control groups. Evidence Rating Level: 2 (Good) Study Rundown: Delirium is viewed as an acute onset, potentially fluctuating state of disorganized thought or altered levels of consciousness. Postoperative recovery can often include...
1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology later in life. While these are components of early-life cognitive enrichment (ECLE),...
1. This protein-wide association study found that eight specific proteins were associated with cognitive resilience in older adults, pointing toward targets for novel therapies. Evidence Rating Level: 2 (Good) Many primary causes of dementia occur among older adults present without commonly recognized neuropathological signatures. Proteomics can be useful in identifying proteins...