Tag: Alzheimer’s disease

1. Causes of death reported on death certificates drastically underestimated dementia mortality burden by a factor of 2.7. 2. Non-Hispanic Black persons demonstrated significantly greater mortality burden than non-Hispanic White persons. Evidence Rating Level: 2 (Good) Dementia is a leading cause of death in the US and abroad, with Alzheimer’s disease accounting...
1. Delirium was significantly associated with long-term cognitive decline. 2. Across all studies, delirium groups demonstrated worse cognitive outcomes than control groups. Evidence Rating Level: 2 (Good) Study Rundown: Delirium is viewed as an acute onset, potentially fluctuating state of disorganized thought or altered levels of consciousness. Postoperative recovery can often include...
1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology later in life. While these are components of early-life cognitive enrichment (ECLE),...
1. This protein-wide association study found that eight specific proteins were associated with cognitive resilience in older adults, pointing toward targets for novel therapies. Evidence Rating Level: 2 (Good) Many primary causes of dementia occur among older adults present without commonly recognized neuropathological signatures. Proteomics can be useful in identifying proteins...
Association of Early-Life Cognitive Enrichment With Alzheimer’s Disease Pathological Changes and Cognitive Decline 1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology...
1. Lower RBFOX1 was associated with greater amyloid burden in the prefrontal cortex. 2. Reduced RBFOX1 was associated with increased rate of decline and reduced neurocognitive performance, and may be a novel locus for preclinical and early Alzheimer’s disease. Evidence Rating Level: 1 (Excellent) Study Rundown: Genome-wide association studies (GWAS) have identified greater...
Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis 1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic...
1. There is a significantly increased risk of dementia in patients with previously diagnosed depression, with the highest risk observed in patients diagnosed with severe depression Evidence Level: 2 (Good) The prevalence of dementia is on the rise. With a scarcity of effective treatment options, increased emphasis has been placed on the...
1. Flortaucipir-PET and CSF modalities for assessing tau pathology not only differ in results in early Alzheimer’s dementia (AD) but suprathreshold CSF P-tau may be indicative of early AD that is unrecognizable via cognitive testing. 2. CSF P-tau may provide evidence of disease progression that early fortaucipir-PET cannot sufficiently detect. Evidence...
Electronic Cigarette and JUUL Use Among Adolescents and Young Adults 1. The use of electronic cigarettes is highly prevalent among adolescents and young adults through the advent of JUUL, which has unique implications for this young and susceptible age group. Evidence Rating Level: 1 (Excellent) Adverse effects of nicotine on overall health,...