Tag: antibiotic

1. A double-blinded, randomized controlled trial found that there were no significant differences between afebrile men treated for 7 days versus 14 days of ciprofloxacin or trimethoprim/sulfamethoxazole for urinary tract infection. 2. More than 90% of patients in both groups achieved the primary outcome of symptom resolution by day 14...

1. A six-week antibiotic therapy was not shown to be non-inferior to a 12-week antibiotic therapy for patients with confirmed prosthetic joint infections. 2.The six-week therapy resulted in more unfavorable outcomes for patients compared to the 12-week therapy. Evidence Rating Level: 1 (Excellent)      Study Rundown: Treatment of prosthetic joint infections (PJI) is challenging...

1. A six-week antibiotic therapy was not shown to be non-inferior to a 12-week antibiotic therapy for patients with confirmed prosthetic joint infections. 2.The six-week therapy resulted in more unfavorable outcomes for patients compared to the 12-week therapy. Evidence Rating Level: 1 (Excellent)      Study Rundown: Treatment of prosthetic joint infections (PJI) is...

1. In a large retrospective cohort study, adolescents prescribed fluoroquinolone antibiotics were at a slightly increased risk of experiencing tendinitis or tendon rupture compared to those who took other antibiotics. 2. The increased risk of tendon rupture associated with fluoroquinolone use was extremely small, with a number needed to treat...

1. There was no difference in follow-up symptom severity between patients who received immediate or delayed antibiotics for respiratory tract infections. 2. Delaying antibiotics was associated with higher patient satisfaction, lower complications, and fewer reconsultations compared to not receiving any antibiotics.  Evidence Rating Level: 1 (Excellent)  Study Rundown: In 2016, the CDC...

1. Cure at 15 days occurred in 77% of patients in the placebo (3-day therapy) group compared to 68% of patients in the β-lactam (8-day therapy) group. 2. Incidence of adverse events was similar between both groups (14% placebo vs. 19% β-lactam).  Evidence Rating Level: 1 (Excellent) Study Rundown: Lower respiratory tract...

1. Five-day treatment of community-acquired pneumonia in children was comparable to standard, 10-day treatment. Evidence Rating Level: 2 (Good) Community-acquired pneumonia (CAP) is a common presenting illness among children. Due to the high occurrence, it is important to understand the most appropriate treatment for CAP among this age group. This study aimed...

Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis 1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic...

1. In this retrospective cohort study, excess days of antibiotic treatment were not associated with reduced adverse outcomes. 2. Patients who took prolonged doses of antibiotics beyond the shortest recommended dose in guidelines reported a greater number of adverse events. Evidence Rating Level: 2 (Good) Study Rundown: Pneumonia affects a large proportion of...

1. In this retrospective cohort study, excess days of antibiotic treatment were not associated with reduced adverse outcomes. 2. Patients who took prolonged doses of antibiotics beyond the shortest recommended dose in guidelines reported a greater number of adverse events. Evidence Rating Level: 2 (Good) Study Rundown: Pneumonia affects a large proportion...