Tag: antibiotic

Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis 1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic...
1. In this retrospective cohort study, excess days of antibiotic treatment were not associated with reduced adverse outcomes. 2. Patients who took prolonged doses of antibiotics beyond the shortest recommended dose in guidelines reported a greater number of adverse events. Evidence Rating Level: 2 (Good) Study Rundown: Pneumonia affects a large proportion of...
1. In this retrospective cohort study, excess days of antibiotic treatment were not associated with reduced adverse outcomes. 2. Patients who took prolonged doses of antibiotics beyond the shortest recommended dose in guidelines reported a greater number of adverse events. Evidence Rating Level: 2 (Good) Study Rundown: Pneumonia affects a large proportion...
1. 100% of children with low-risk symptoms such as rash and itching were negative for true penicillin allergies after 3-tier testing. 2. Rash and itching were reported to be the most common reactions misclassified as penicillin allergies by parents. Evidence rating level: 4 (Below Average) Study Rundown: Although penicillin is the most...
1. In this prospective stepped-wedge participatory intervention study, implementation of a behavioral antimicrobial stewardship program which maintained prescriber autonomy resulted in improved appropriateness of antimicrobial prescribing in hospitals. 2. Despite the improvement in appropriate antibiotic prescribing practices, there was no decrease in total antimicrobial consumption. Evidence Rating Level: 2 (Good) Study Rundown:...
1. In a retrospective study of over 300 acute care hospitals across the United States, overall days of therapy (DOT) for antibiotic use and proportion of admitted patients receiving antibiotics remained consistent over time from 2006 to 2012. 2. Use of certain antibiotic classes decreased over time, including aminoglycosides, first...
1. According to this randomized, double-blind, placebo-controlled trial carried out in the United Kingdom, there was no significant difference in symptom scores in adults with acute asthma exacerbations when prescribed azithromycin compared with placebo. 2. This study had recruitment issues since almost half of screened participants were excluded due to...
1. Based on this randomized controlled trial conducted in Spain about hospitalized patients with community acquired pneumonia, treatment with a shorter course of antibiotics driven by clinical factors was equally effective compared with a regimented, longer course of antibiotics. 2. Since the majority of the patients received fluoroquinolone-class antibiotics and...
1. The annual antibiotic prescription rate in 2010-2011 was 506 per 1000 population, with only 353 estimated to be appropriate. 2. The diagnoses associated with the highest rates of antibiotic prescription were sinusitis, suppurative otitis media and pharyngitis. Evidence Rating Level: 2 (Good) Study Rundown: Antibiotic-resistant pathogens are on the rise and are...
1. Postdischarge oral antibiotic therapy for acute osteomyelitis in children did not result in more treatment failure as compared to intravenous antibiotics. 2. Children treated with intravenous antibiotics through a peripherally inserted central catheter (PICC) line had a higher risk of requiring an emergency department visit or hospitalization due to...