Tag: antiretroviral

1. Pairwise comparisons of tenofovir-emtricitabine and ritonavir-boosted lopinavir (TDF-FTC-LPV/r), zidovudine-lamivudine and ritonavir-boosted lopinavir (ZDV-3TC-LPV/r), and tenofovir-emtricitabine and ritonavir-boosted atazanavir (TDF-FTC-ATV/r) HIV regimens among pregnant women with HIV showed all three regimens had comparable risks of preterm birth, low birth weight, and neonatal death. 2. There was a higher risk of...
1. Children less than 8 years old infected with HIV and children who were HIV exposed-but-uninfected had poorer neurodevelopmental outcomes compared to unexposed children. 2. Those children who were either HIV-infected or exposed-but-uninfected who also had anti-retroviral exposure may have lower neuropsychological function than those without anti-retroviral exposure. Evidence Rating Level:...
1. Individuals infected with HIV-1 who were randomized to receive antiretroviral therapy (ART) at trial enrollment had a 97% and 93% lower risk of transmitting the virus compared to those who were randomized to receive ART on a delayed basis (when CD4+ count fell below 25 or when there...
1. This prospective study found no instances of HIV transmission among serodiscordant couples engaging in condomless sexual intercourse when the HIV-infected partner was taking antiretroviral therapy and maintaining a viral load below 200 copies/mL. 2. The calculated upper limit of HIV transmission risk in these couples is 0.3 per 100...
1. In human immunodeficiency virus (HIV)-seronegative men and transgender women who have sex with men, preexposure prophylaxis with antiretrovirals significantly reduced the risk of HIV infection when compared with placebo. 2. There were similar rates of serious adverse events in both groups, though patients taking antiretroviral preexposure prophylaxis were significantly...
1. Asymptomatic, HIV-positive adults with CD4 cell counts above 500 who were initiated on antiretroviral therapy (ART) immediately had significantly fewer serious AIDS-related events and serious non-AIDS events, compared to similar individuals whose therapy was deferred until development of AIDS or another condition prompting ART treatment. 2. These findings were...
Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes HMG-CoA reductase inhibitors (statins) lower LDL cholesterol levels and reduce the risk of cardiovascular events. Ezetimibe is a non-statin lipid lowering medication that reduces the absorption of cholesterol in the intestines and can further decrease LDL cholesterol levels when added...
1. In HIV patients, equivalent rates of virologic control were seen between antiretroviral regimens of emtricitabine and tenofovir disproxil fumarate (TDF) paired with ritonavir-boosted atazanavir, ritonavir-boosted darunavir, or raltegravir. 2. Treatment with raltegravir or ritonavir-boosted darunavir demonstrated better tolerability compared to ritonavir-boosted atazanavir. Evidence Rating Level: 1 (Excellent) Study Rundown: Two reverse...
1.  In this study cohort, patients who were HIV positive had a lower risk of developing multiple sclerosis.  2. This report complements the ongoing clinical trial using Raltegravir to treat relapsing-remitting multiple sclerosis.  Evidence Rating Level: 2 (Good)  Study Rundown: Cases of patients infected with Human Immunodeficiency Virus (HIV) with co-morbid multiple...
1. Among adults who underwent HIV self-testing in Malawi, offering home initiation of care increased anti-retroviral therapy initiation compared to standard HIV care. 2. Combined across both study groups, 72.5% of ART initiators were still taking ART six months after diagnosis. Evidence Rating Level:  1 (Excellent) Study Rundown: Testing for HIV and...