Tag: bacterial meningitis

1. In this cluster-randomized trial involving Australian adolescents, administration of 4CMenB did not result in lower prevalence of carriage of any disease-causing genogroup of N. meningitidis at 12 months. 2. While 4CMenB may decrease the likelihood of late cases in outbreaks, its ineffectiveness in reducing transmission means that antibiotics remain...

1. In this cluster-randomized trial involving Australian adolescents, administration of 4CMenB did not result in lower prevalence of carriage of any disease-causing genogroup of N. meningitidis at 12 months. 2. While 4CMenB may decrease the likelihood of late cases in outbreaks, its ineffectiveness in reducing transmission means that antibiotics remain...

1. College students were at significantly higher risk of contracting meningococcus serotype B (MenB) disease compared with noncollege students in the same age group. 2. Less than 25% of college students who contracted meningococcal disease had received at least one dose of the MenB vaccine. Study Rundown: While the overall incidence...

1. The overall effectiveness of the meningococcal conjugate vaccine between 0 and 8 years post-vaccination was 69%. 2. The vaccine effectiveness (VE) was 79% at <1 year from vaccination, 69% at 1 to 3 years from vaccination, and 61% at 3 to 8 years from vaccination. Evidence Rating Level: 3 (Fair) Study...

1. Adjunctive dexamethasone for HIV-associated cryptococcal meningitis did not reduce mortality. 2. Adjunctive dexamethasone for HIV-associated cryptococcal meningitis was associated with more adverse events and disability compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: HIV-associated cryptococcal meningitis causes approximately 600,000 deaths each year. For certain CNS infections, such as...

Image: PD 1. Moderate hypothermia (32°C- 34°C) did not improve clinical outcomes of bacterial meningitis patients. 2. Among the patient sample, 86% of the hypothermia group and 74% of the control group experienced unfavorable outcomes. Evidence Rating Level: 1 (Excellent) Study Rundown: Therapeutic hypothermia has been shown in animal models to decrease intracranial...