Tag: cardiovascular risk

1. Ziltivekimab lowered high-sensitivity CRP levels, a predictor of vascular events, compared to placebo in a dose-dependent manner. 2. Thrombotic biomarkers including fibrinogen, serum amyloid A, haptoglobin, secretory phospholipase A2, and lipoprotein were lower in treatment groups compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Prior studies, including the landmark...
1. Regardless of cardiovascular disease history and baseline blood pressure, a 5 mmHg reduction in systolic blood pressure reduced relative risk of major cardiovascular events by 10%. 2. These findings support considering antihypertensive medications for patients with increased cardiovascular risk, even those who are normotensive at baseline.  Evidence Rating Level: 1...
1. Patients without standard modifiable cardiovascular risk factors (SMuRFs) had a significantly higher all-cause mortality at 30 days after first presentation of STEMI. 2. Patients without SMuRFs were significantly less likely to receive statins, ACEIs, ARBs, or beta-blockers at discharge.  Evidence Rating Level: 2 (Good) Study Rundown: Standard modifiable cardiovascular risk factors...
1. Combined use of intracoronary near-infrared spectroscopy (NIRS) and intravascular ultrasound were effective at detecting untreated intracoronary lesions at high risk of major adverse cardiac event (MACE). 2. Highly lipidic lesions and large plaque burden were found to be independent predictors of non-culprit lesion-related MACEs. Evidence Rating Level: 2 (Good) Study Rundown:...
1. The use of long-term transdermal estrogen for castration therapy for prostate cancer showed no difference in cardiovascular events versus current standard of care. 2. Gynecomastia was significantly more common in the transdermal estrogen group than standard of care group. Evidence Rating Level: 1 (Excellent) Study Rundown: Prostate cancer, an ongoing major...
1. Patients who received low-dose colchicine daily had a ~30% lower risk of cardiovascular events compared to those who received placebo. 2. Although the incidence of cardiovascular death was similar between groups, the colchicine group had a numerically greater number of non-cardiovascular deaths as well as all-cause deaths compared to...
1. Findings from this cohort study suggest that diets including processed meat, unprocessed, or poultry have significant associations with incidence of cardiovascular disease while fish do not 2. Processed meats and unprocessed red meats have significant association with all-cause mortality while poultry and fish did not Evidence Rating: 2 (Good) The concept...
1. In this prospective cohort study involving patients who had inpatient noncardiac surgery, those with N-terminal pro-B-type natriuretic peptide (NT-proBNP) values of greater than 100 pg/mL were far more likely to suffer myocardial injury or vascular death compared to those with NT-proBNP values of less than 100 pg/mL. 2. Elevated...
1. The risk of major cardiovascular events may be further reduced with the addition of fenofibrate therapy to statin treatment in adults with metabolic syndrome. Evidence Rating Level: 2 (Good) Metabolic syndrome is associated with an increased risk of atherosclerotic cardiovascular disease; this risk is partly attributable to accompanying atherogenic dyslipidemia....
1. In this prospective cohort study, higher 24-hour and nighttime blood pressure measurements were significantly associated with greater risks of death and a composite cardiovascular (CV) outcome. 2. 24-hour and nighttime blood pressure may be considered optimal measurements for estimating CV risk however, there was only a very modest improvement...