Tag: cardiovascular

1. Stopping renin-angiotensin system inhibition in patients with advanced chronic kidney disease was associated with higher risk of mortality, major cardiovascular events, and lower risk of kidney replacement therapy. Evidence Rating Level: 2 (Good) Studies have shown that renin-angiotensin system inhibitors (RASi) are effective in delaying chronic kidney disease (CKD) progression. Angiotensin-converting enzyme...

1. Positive fecal immunochemical test (FIT) results were associated with increased incidences of ischemic stroke, myocardial infarction, and all-cause mortality. Evidence Rating Level: 2 (Good) While fecal immunochemical tests (FIT) is a commonly used and effective screening tool for colorectal cancer (CRC), their clinical use in detecting other diseases is poorly known....

1. The rate of clinical events and all-cause mortality was similar in patients with drug-coated balloon therapy compared to those with drug-eluting stent therapy. 2. Treatment with drug-coated balloons yielded non-significantly decreased rates of major bleeding and probable or definite stent thrombosis.  Evidence Rating Level: 1 (Excellent) Study Rundown: Drug-coated balloons (DCBs)...

1. Sotagliflozin was shown to lower the risk of total number of deaths from cardiovascular causes and hospitalizations and urgent visits for heart failure in patients with diabetes and recent worsening heart failure compared to placebo. 2. Sotagliflozin was shown to be similar in the percentage of patients with adverse...

1. Patients who received rivaroxaban had a statistically significantly longer mean time until occurrence of a major clinical event compared to those who received warfarin. 2. The incidence of secondary-outcome events such as transient ischemic attack (TIA), valve thrombosis, and non-CNS embolism were similar between groups. Evidence Rating Level: 1 (Excellent) Study...

1. A 6% risk reduction for developing hypertension was associated with a 1-point improvement in Life’s Simple 7 score, a metric for cardiovascular health. Evidence Rating Level: 2 (Good) Hypertension is a condition that affects roughly half of the adult US population, and is a known risk factor for cardiovascular disease...

1. Patients who received low-dose colchicine daily had a ~30% lower risk of cardiovascular events compared to those who received placebo. 2. Although the incidence of cardiovascular death was similar between groups, the colchicine group had a numerically greater number of non-cardiovascular deaths as well as all-cause deaths compared to...

1. The standardized Ready to Reduce Risk (3R) program resulted in improvements to lifestyle among those taking medication for prevention of cardiovascular disease. 2. 3R did not improve medication adherence compared to the control group. Evidence Rating Level: 2 (Good) Nearly one-third of deaths across the globe are attributable to cardiovascular disease...

1. Patients status-post placement of drug-eluting stents (DES) for acute coronary syndrome received three months of Ticagrelor and Aspirin dual-antiplatelet therapy (DAPT), followed by nine months of DAPT or Ticagrelor monotherapy. 2. At one year, patients who received Ticagrelor alone experienced significantly fewer adverse major bleeding events. There was no...

1. Gut Bacterial Species Shown to Lower Fecal and Serum Cholesterol Levels in Humans Evidence Rating Level: 2 (Good) High serum cholesterol levels have been linked to cardiovascular disease, the cause of 1 in 4 deaths in all industrialized countries. Reducing cholesterol transport in the intestine, as demonstrated by ezetimibe, a...