Tag: cholesterol

Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma 1. Having a prior tonsillectomy was correlated to a greater risk of developing esophageal adenocarcinoma, with an odds ratio of 1.7. Evidence Rating Level: 2 (Good) Esophageal adenocarcinoma (EAC) is a subtype of esophageal cancer that has gradually grown in incidence...
1. Gut Bacterial Species Shown to Lower Fecal and Serum Cholesterol Levels in Humans Evidence Rating Level: 2 (Good) High serum cholesterol levels have been linked to cardiovascular disease, the cause of 1 in 4 deaths in all industrialized countries. Reducing cholesterol transport in the intestine, as demonstrated by ezetimibe, a...
1. In this cohort of women, those who experienced migraines with aura were associated with an increased adjusted incidence rate for major cardiovascular diseases (CVD) compared to those with migraines without aura or no migraines. 2. After diabetes and smoking, migraines with aura were found to have the highest CVD...
1. Exclusive breastfeeding in the first 3 months of life, as opposed to mixed breast and bottle feeding and exclusive bottle feeding, was associated with lower low-density lipoprotein (LDL) cholesterol and lower total cholesterol in adolescence. 2. There was no association between exclusive breastfeeding and body mass index (BMI) or...
1. In this systematic review and meta-analysis, more intensive compared with less itensive LDL-C lowering was associated with a greater reduction in risk of total and cardiovascular mortality in trials of patients with higher baseline LDL-C levels. 2. The greatest benefit from LDL-C lowering therapy occurred for patients with baseline...
1. In the absence of risk factors, there was low prevalence of increased ASCVD risk in women under 50 and men under 40. 2. Only 2.9% of the low-prevalence subgroups for cardiovascular risk had high LDL-C levels. Evidence Rating Level: 2 (Good) Study Rundown: Screening for dyslipidemia is an important component of...
1. When added to statin therapy, the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor bococizumab significantly reduced the risk of cardiovascular events in patients with low density lipoprotein cholesterol (LDL-C) levels greater than 100 mg/dL, but had no benefit in patients with LDL-C lower than 100 mg/dL. 2. Combined analyses,...
1. This multi-year, open-label extension of phase 2 trials examining the LDL-lowering efficacy of evolocumab (PCSK9-inhibitor) showed that evolocumab plus standard of care lipid lowering therapy had continued lipid lowering response after over four years of follow-up. 2. Significant adverse events, including new-onset diabetes, neurocognitive complications, or development of neutralizing...
1. This prospective cohort study, conducted in Copenhagen, found that mild-to-moderate levels of non-fasting hypertriglyceridemia, from 177 mg/dL (2 mmol/L) and above, were associated with increased risk of acute pancreatitis. 2. These increases in risk for acute pancreatitis were greater than the corresponding risk of myocardial infarction within the same...
1. In the 1970s, observational data suggested a direct link between serum cholesterol levels and the risk of coronary heart disease (CHD). 2. This trial was one of the first large, randomized studies to demonstrate that reducing lipid levels with cholestyramine could significantly lower death from CHD and nonfatal myocardial...