PCSK9 antibodies safe and effective in treating dyslipidemia
1. From a systematic review, proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies significantly reduced LDL cholesterol levels and all-cause mortality ...
Tag: cholesterol
Alirocumab linked to significant and sustained reduction in LDL cholesterol [ODYSSEY LONG TERM]
1. In patients on maximal statin treatment and with LDL levels over 70mg/dL, the addition of alirocumab reduced LDL levels ...
Evolocumab plus standard therapy reduces LDL, cardiovascular events compared to standard anti-cholesterol therapy alone [OSLER-1 & OSLER-2 Trials]
1. Compared to those treated with only standard therapy, patients treated with the addition of evolocumab, a monoclonal antibody that ...
2 Minute Medicine Rewind March 9 – March 15, 2015
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Randomized ...
![Type I diabetes not associated with early menopause [OVADIA study]](https://www.2minutemedicine.com/wp-content/uploads/2014/12/diabetes1_edited-350x250.jpg)
Familial hypercholesterolemia linked with lower prevalence of type 2 diabetes mellitus
1. The prevalence of type 2 diabetes mellitus was significantly lower in patients with familial hypercholesterolemia compared to unaffected relatives. ...
Inhibiting cholesterol uptake decreases growth of pancreatic tumors [PreClinical]
1. Metabolic profiling of cells from mice bearing spontaneous pancreatic ductal adenocarcinoma (PDAC) revealed high upregulation of genes relating to ...
Key mutations may protect against coronary artery disease
1. Genetic mutations that led to the inactivation NPC1L1, a lipid transporter protein, were linked to lower low-density lipoprotein (LDL) ...
Cholesterol-containing lipid particles protect mice from lethal bacterial toxins
1. Liposomes, small spheres composed of lipids, were engineered to contain artificially high cholesterol (Chol) concentrations to promote preferential binding ...
Evolocumab significantly reduces LDL cholesterol in familial hypercholesterolemia patients [TESLA-B and RUTHERFORD-2 studies]
1. : In patients with homozygous familial hypercholesterolemia, evolocumab significantly reduced LDL cholesterol levels. The regimen was well-tolerated with no ...
Ezetimibe (Zetia, Vytorin) use declining after ENHANCE trial publication in 2008
1. After the publication of the ENHANCE trial results, there was a significant decrease in the number of new initiations ...