Hereditary erythrocytosis is associated with a fetal-like EPO isoform
1. This case series identified three non-coding erythropoietin (EPO) variants that significantly increased gene expression under hypoxic conditions. 2. The ...
Tag: chronic disease
Tolebrutinib not superior to teriflunomide in reducing relapsing multiple sclerosis relapse rates
1. In concurrent randomized controlled trials (GEMINI 1 and GEMINI 2) of patients with relapsing multiple sclerosis (RMS), tolebrutinib did ...
Tolebrutinib reduces disability progression in nonrelapsing secondary progressive multiple sclerosis
1. In this randomized controlled trial of patients with nonrelapsing secondary progressive multiple sclerosis (SPMS), oral tolebrutinib reduced the risk ...
Pulsed field ablation noninferior to cryoablation for reducing paroxysmal atrial fibrillation recurrence
1. In this randomized controlled trial of patients with symptomatic paroxysmal atrial fibrillation, pulsed field ablation (PFA) was noninferior to ...
Physical disability and psychological distress demonstrate marked progression after diagnosis of cancer
1. In this Australian cohort of adults, individuals diagnosed with cancer experienced greater declines in physical functioning and slightly higher ...
Social isolation is a marker of increased mortality and cardiovascular risk in patients with chronic kidney disease
1. In this prospective cohort study, social isolation is associated with decreased survival time and accelerated onset of cardiovascular disease ...
2 Minute Medicine Rewind May 26, 2025
Exposure Therapy in Mixed Reality for Obsessive-Compulsive Disorder: A Randomized Clinical Trial 1. In this randomized clinical trial, mixed reality ...
Lepodisiran, a long-duration small interfering RNA, reduces lipoprotein(a) levels
1. Lepodisiran, a long-duration small interfering RNA targeting lipoprotein(a) synthesis, reduced serum concentrations of lipoprotein(a) compared to placebo in adults ...
Twice-yearly lenacapavir prevents HIV more effectively than daily F/TDF
1. In this randomized controlled trial, among men and gender-diverse persons who have sex with men, it was found that ...
Left atrial appendage closure is noninferior to oral anticoagulation after ablation for atrial fibrillation
1. In this randomized trial, left atrial appendage closure was associated with lower bleeding than oral anticoagulation in patients who ...
