Tag: chronic kidney disease

1. Patients managed with intensive blood pressure reduction were found to have significantly greater decreases in kidney damage biomarkers compared to standard blood pressure management. 2. Higher levels of kidney damage biomarkers at baseline were associated with greater odds of developing chronic kidney disease. Evidence Rating Level: 2 (Good) Study Rundown: Systolic...
1. Patients with end-stage renal disease (ESRD) have significantly worse survival outcomes following left ventricular assist device (LVAD) implantation compared to recipients without ESRD. 2. The median time to death was substantially shorter in those with ESRD, with many patients dying during the index hospitalization. Evidence Rating Level: 2 (Good) Study Rundown:...
1. The kidney failure risk equation (KFRE), currently used in adults to estimate risk for progression to end-stage renal disease (ESRD) based on demographic and laboratory data, also provides excellent discrimination of ESRD risk in a pediatric cohort with chronic kidney disease. 2. The performance of the KFRE in predicting...
1. In a meta-analysis of randomized trials evaluating blood pressure control in patients with stage 3-5 chronic kidney disease (CKD), more intensive blood pressure lowering was associated with reduction in all-cause mortality. 2. In sensitivity analysis, trials demonstrating a greater blood pressure reduction were associated with greater reductions in all-cause...
1. While osteoporosis medications may have some benefits in chronic kidney disease patients (CKD), the evidence is unclear with respect to their impact on bone mineral density (BMD) and fracture risk. 2. The safety of osteoporosis medications among CKD patients is not clearly established. Evidence Rating Level: 1 (Excellent) Study Rundown: CKD...
1. Metformin use is associated with reduced all-cause mortality in patients with chronic kidney disease, congestive heart failure, or chronic liver disease with hepatic impairment. 2. In this systemic review, fewer heart failure readmissions were observed in patients with CKD or CHF that were treated with metformin. Evidence Rating Level: 1...
1. This study quantified sodium intake by measuring the 24-hour urinary sodium excretion, and found that among patients with chronic kidney disease (CKD), a greater level of sodium excretion (and thus higher sodium consumption) was associated with an increased incidence of cardiovascular disease (CVD). 2. Elevated sodium consumption was also...
1. From this systematic review and meta-analysis, use of erythropoietin-stimulating agents (ESAs) to achieve high hemoglobin targets in patients with chronic kidney disease (CKD) did not significantly improve health-related quality of life (HRQOL) compared to using ESAs to achieve lower hemoglobin targets. Evidence Rating Level: 1 (Excellent) Study Rundown: Erythropoietin-stimulating agents...
  1. Amongst two prospective cohorts, use of proton pump inhibitors (PPIs) was associated with a 20 – 50% higher risk of developing chronic kidney disease (CKD). This same risk was not present with the use of H2-antagonists, which are prescribed for the same indications as PPIs. 2. Given the...
1. Depletion of dynamin, a protein involved in maintenance of the actin cytoskeleton, resulted in decreased circulation of large proteins in zebrafish, which modeled the presence of protein in patient urine (proteinuria). 2. Administration of the small molecule Bis-T-23, which induces dynamin activity, reduced both transient and chronic proteinuria...