Artificial Intelligence and Real World Data Speed Up Drug Development
Key points:1. TriNetX is using real world data to reduce clinical trial enrollment time by as much as 40 percent2. ...
Tag: clinical trial
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2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [May 23rd, 2025]
Food and Drug Administration to Fully Integrate Generative Artificial Intelligence by JuneThe Food and Drug Administration is diving headfirst into ...
RAMOSE Phase II trial finds promising results for osimertinib and ramucirumab in non-small cell lung cancer
1. Treatment of patients with tyrosine kinase inhibitor (TKI)-naïve epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) with ...
Dose-dense adjuvant therapy with epirubicin and cyclophosphamide effective for breast cancer
1. Dose-dense adjuvant chemotherapy involving sequential epirubicin/cyclophosphamide and docetaxel showed improved breast cancer recurrence-free survival and event-free survival compared to ...
Phase I trial of novel CAR-T cell therapy for pediatric midline gliomas
1. Approximately 88% of patients with GD2-positive diffuse midline glioma or other progressive CNS tumours receiving C7R-GD2.CARTs had a partial ...
A large language model demonstrates superior cost-effectiveness in screening heart failure candidates for clinical trials
1. Unlu and colleagues compared RECTIFIER, a large language model (LLM), against human study staff to evaluate patient eligibility for ...
Mustang Bio & City of Hope: CAR-T Cell Therapy Extends Treatment Refractory Glioblastoma Survival
Half the individuals receiving the new CAR-T cell therapy achieved stable disease or better. Intratumoral, intraventricular, and intratumoral + intraventricular ...
Study site selection in trials pertaining to transcatheter valvular therapies can affect the socioeconomic makeup of the sample
1. Amongst hospitals with a cardiac surgery department, 11.5% participated actively in research trials of transcatheter mitral or tricuspid therapies. ...
Combination therapy using conformation-specific KIT inhibitors associated with clinical benefit in patients with advanced gastrointestinal stromal tumors
1. The use of a type I KIT inhibitor, such as PLX9486, in combination with a type II inhibitor, such ...
Oral glucose tolerance test preferred for pre-diabetes screening in PCOS
Image: PD Human Ovarian Follicle 1. HbA1c and fasting plasma glucose (FPG) demonstrated low sensitivity in detecting pre-diabetes in ...