A novel therapy targeting γ-aminobutyric acid is safe and may be effective in major depressive disorder
1. H3-10353, a novel γ-aminobutyric acid (GABA) positive allosteric modulator, is safe and well-tolerated in healthy patients and those with ...
Tag: clinical trial
Pyrotinib provides survival benefit in human epidermal growth factor receptor 2-positive metastatic breast cancer when combined with trastuzumab and docetaxel
1. Pyrotinib combined with trastuzumab and docetaxel prolonged progression-free survival compared to placebo combined with trastuzumab and docetaxel in patients ...
Oral remibrutinib hits Phase 3 primary endpoint for inducible hives
1. Oral remibrutinib successfully met its primary endpoint in the Phase III RemIND trial, delivering significant symptom relief for chronic ...
The Scan by 2 Minute Medicine®: Daily caffeine intake linked to lower dementia risk, AAP sues over federal vaccine schedule overhaul, Catherine O’Hara passes away after short illness, and GLP-1 receptor agonists reduce endometrial cancer risk
The Scan by 2 Minute Medicine® is a pop-culture medical newsletter and exclusive benefit for 2 Minute Medicine Plus subscribers. ...
The Scan by 2 Minute Medicine®: Oral GLP 1 reshapes obesity visits, deepfake doctors fuel DIY injectables, home longevity scales overwhelm clinics, and TV CPR scripts leave bystanders unprepared
The Scan by 2 Minute Medicine® is a pop-culture medical newsletter and exclusive benefit for 2 Minute Medicine Plus subscribers. ...
An electronic intervention may increase chances of benzodiazepine cessation
1. An electronic intervention promoting self-management of benzodiazepine cessation significantly increased the chances of benzodiazepine cessation compared to placebo. Evidence ...
FDA highlights flexible chemistry manufacturing controls expectations for cell and gene therapies
1. New FDA communication introduces a more flexible, risk‑based chemistry, manufacturing, and controls (CMC) framework for cell and gene therapies, ...
Exercise may improve physical function and psychological well-being following COVID-19 infection in adults
1. Resistance exercise for three months improved physical function and psychological well-being among adults after COVID-19 infection. Evidence Rating Level: ...
Revumenib may be safe and effective in the treatment of nucleophosmin 1-mutated acute myeloid leukemia
1. In pretreated patients with nucleophosmin 1-mutated (NPM1m) acute myeloid leukemia (AML), nearly half of patients treated with revumenib showed ...
mFOLFIRINOX may have a limited role in pancreatic cancer in Phase II/III trial
1. In patients with metastatic pancreatic cancer, neither modified fluorouracil, leucovorin, irinotecan and oxaliplatin (mFOLFIRINOX) or S-1, irinotecan and oxaliplatin ...
