Tag: Clostridium difficile

1. In this study, spores of non-toxigenic Clostridium difficile (C. difficile; M3 strain) administered for prevention of recurrent C. difficile infection were generally well tolerated with adverse events occurring in only 3% of individuals receiving this intervention. 2. Rates of recurrent C. difficile infection were lower in individuals receiving non-toxigenic...
1. Clostridium difficile (C. difficile) infection is often seen in hospitalized patients who take antibiotics. 2. Antibiotic prescribing patterns on the ward-wide level were associated with incidence of C. difficile infection.  Evidence Rating Level: 2 (Good)     Study Rundown: Clostridium difficile is a bacterium that produces copious watery diarrhea, and is...
1. A frozen fecal microbiotia transplant was effective in resolving diarrhea in individuals with refractory or recurrent Clostridium difficile infection. 2. The frozen fecal microbiota transplant was safe, as no serious adverse events were observed in the 20-person test group. Evidence Rating Level: 2 (Good)            Study Rundown: Despite treatment...
Classics Series, Landmark Trials in Medicine
1. Treating recurrent C. difficile infection with infusion of donor feces resulted in significantly higher cure rates than treating with vancomycin-alone or vancomycin with bowel lavage. 2. Adverse events immediately after feces infusion included diarrhea, cramping, and belching. Original Date of Publication: January 31, 2013 Study Rundown: Previous studies have demonstrated that...
Classics Series, Landmark Trials in Medicine
1. Fidaxomicin is non-inferior to vancomycin in achieving clinical cure of C. difficile infection 2. Fidaxomicin therapy significantly reduces the rate of recurrence and significantly increases the rate of global cure of C. difficile infection when compared with vancomycin therapy Original Date of Publication: February 3, 2011 Study Rundown: Clostridium difficile infection...
Image: PD  1. The administration of microbial preparations to inpatients at risk of developing antibiotic-associated diarrhea (AAD) or Clostridium difficile diarrhea (CDD) is no longer recommended.  Evidence Rating Level: 1 (Excellent)  Study Rundown: Use of probiotic preparations has become an increasingly popular modality for the maintenance of bowel health. Several recent meta-analyses...