Tag: cognition

1. Metformin was found to be safe and tolerable in survivors of pediatric brain tumors. 2. Metformin was associated with retention of memory and processing speed abilities, as well as a reduction of white matter loss. Evidence Rating Level: 1 (Excellent) It is believed that endogenous neural precursor cells (NPCs) can promote...
Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19) 1. No association was found between angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker use and test-positivity for COVID-19. Evidence Rating Level: 2 (Good) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the...
1. In a systematic review, awake prone positioning (tummy time) in healthy infants was positively associated with total development, gross motor development, decreased body mass index (BMI), prevention of brachycephaly, and ability to move while prone, supine, crawling, and rolling. 2. These results support the World Health Organization’s (WHO) recommendation...
1. In this single-center, cross-sectional study, longer time from injury to sports medicine clinic assessment was linked with an increased time to recovery. 2. Visual motion sensitivity symptoms were also significantly associated with recovery time in the analysis of this cohort. Evidence Rating Level: 3 (Average)  Study Rundown: Concussion is a common...
1. Adenotonsillectomy done for obstructive sleep apnea (OSA) in children ages 3-5 years had no effect on cognition over time when compared to controls. 2. Those children who received an adenotonsillectomy did demonstrate improvements in sleep patterns on polysomnogram, improvement in parent-reported symptoms, as well as improvements in behavior, daytime...
1. In this systematic review and meta-analysis, there were significantly lower cognitive functioning scores for those who were first-degree relatives of patients with a history of major depressive disorder (MDD). 2. The lower scores for cognitive testing were demonstrated across multiple domains of cognition including IQ, verbal intelligence, perceptual intelligence,...
1. According to a community-based study, diabetes during midlife was associated with increased rates of cognitive decline. 2. Patients with an increased duration of diabetes were associated with increased cognitive decline. Evidence Rating Level: 2 (Good) Study Rundown: There are approximately 20 million adults living in the US with diabetes. Previous research...
Classics Series, Landmark Trials in Medicine
Image: PD 1. Among children exposed to lead early in life, serum lead levels at 24 months of age were significantly associated with decreased cognitive performance on measures of intelligence and educational achievement at 10 years old. 2. Each 0.48 μmol/L (10 μg/dL) increase in serum lead at 24 months of...
Image: PD 1. Longer breastfeeding duration was associated with improved receptive language and IQ in children.  2. Exclusive breastfeeding was associated with superior performance on cognition tests when compared to any breastfeeding and no breastfeeding.  Evidence Rating Level: 2 (Good) Study Rundown: This prospective cohort study found that longer breastfeeding duration was associated...