1. A decline in gait speed paired with domain-specific cognitive decline proved to be strongly correlated with subsequent development of ...
1. This retrospective, multicohort study demonstrated no cross-sectional or longitudinal associations between thyroid dysfunction and global cognition, memory, executive function, ...
1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 ...
1. Preclinical amyloid-β was associated with significant cognitive decline in clinically normal adults across screening and comprehensive measures. 2. Amyloid-β-positive individuals ...
1. Verubecestat, an orally administered beta amyloid precursor protein-cleaving enzyme 1 (BACE-1) inhibitor , did not slow or prevent the progression ...
1. In patients with mild Alzheimer’s disease solanezumab, an antibody designed to facilitate clearance of amyloid-beta plaques, did not significantly ...
1. Physical activity interventions to prevent late-life dementia included aerobic exercise, resistance training, Tai Chi, and multidomain interventions. 2. There ...
1. Pharmacologic treatments had no impact on preventing late-life dementia in patients with normal cognition. 2. Adverse events were increased ...
1. There was inadequate evidence that any over-the-counter (OTC) supplement helped to prevent or delay decline in cognition. 2. The ...
1. In healthy elderly adults, cognitive training enhanced cognitive performance in the area that was trained, but there did not ...
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