Tag: cognitive impairment

1. Metformin was found to be safe and tolerable in survivors of pediatric brain tumors. 2. Metformin was associated with retention of memory and processing speed abilities, as well as a reduction of white matter loss. Evidence Rating Level: 1 (Excellent) It is believed that endogenous neural precursor cells (NPCs) can promote...
1. Pharmacologic treatments had no impact on preventing late-life dementia in patients with normal cognition. 2. Adverse events were increased for several pharmacologic interventions aimed at reducing dementia risk. Evidence Rating Level: 1 (Excellent) Study Rundown: Dementia is a significant clinical syndrome, which affects a large proportion of the aging population. Dementia...
1. By comparing the baseline blood pressures and BP trends of elderly individuals with or without subcortical or cortical microinfarcts at autopsy, the authors identified an association between a steeper BP decline and the presence of subcortical microinfarcts. 2. Cortical microinfarcts were associated with the presence of the apolipoprotein E...
1. In this cross-sectional study of middle-aged adults, radiologic evidence of non-alcoholic fatty liver disease (NAFLD) was associated with reduced total cerebral brain volume (TCBV) as measured by MRI. 2. The estimated brain aging linked with NAFLD was greater for younger patients and the association became less significant in older...
1. In this meta-analysis of available studies, prospective data demonstrated that sleep-disordered breathing (SDB) is associated with an increased risk of developing cognitive impairment. 2. Analysis of cross-sectional studies indicate that SDB is linked to worse executive functioning scores on assessment; with no associated deficits in memory or global cognition. Evidence...
1. In a prospective study of over 360 patients with colorectal cancer (CRC), there was a significant increase in the incidence of cognitive impairment compared to healthy controls. 2. The incidence of cognitive impairment in the CRC population was independent of chemotherapy effects. Evidence Rating Level: 2 (Good) Study Rundown: Although impaired...
1. In this study, physical activity, compared to a health education program, did not result in significant improvements from baseline in global or domain-specific cognitive function in sedentary adults aged 70-89 years. 2. There was also no significant difference in the incidence of mild cognitive impairment (MCI) or dementia between...
1. In this study, stroke survivors showed a faster decline in global cognition and executive function in the years following stroke compared to expected pre-stroke slopes of decline. 2. Stroke was shown to be associated with an acute decline in global cognition, new learning, and verbal memory, however the declines...
1. Amongst older adults in Barcelona, a Mediterranean diet supplemented with either extra virgin olive oil or mixed nuts showed some benefit in slowing down neurocognitive decline. 2. While all adults did have decline in the various neuropsychiatric tests, the amount was lower in the experimental group as compared to...
Very preterm (VPT) infants with small biparietal width (BPW) and increased interhemispheric distance (IHD), measurements of brain growth at term (37-42 weeks gestation) by magnetic resonance imaging (MRI), were both independently associated with impaired cognitive development at age 2. Evidence Rating Level: 2 (Good)   Study Rundown: MRI aids in the...