• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Non-alcoholic fatty liver disease associated with brain volume loss in middle-aged individuals

byJames EnglandandAnees Daud
December 5, 2017
in Chronic Disease, Gastroenterology, Imaging and Intervention, Neurology, Psychiatry
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this cross-sectional study of middle-aged adults, radiologic evidence of non-alcoholic fatty liver disease (NAFLD) was associated with reduced total cerebral brain volume (TCBV) as measured by MRI.

2. The estimated brain aging linked with NAFLD was greater for younger patients and the association became less significant in older participants.

Evidence Rating Level: 3 (Average)    

Study Rundown: The prevalence of NAFLD is rising world-wide and represents the most common cause of chronic liver disease in older adults. Some studies and animal models have suggested a link between NAFLD and cognitive decline, thought in part to be due to shared risk factors. However, some investigations have suggested a more causal relationship with hepatic inflammation and hepatokine release on adverse brain health. As NAFLD is amenable to lifestyle intervention and may represent a modifiable risk factor, understanding the relationship between NAFLD and brain function is important. The current study is a cross-sectional analysis that explored the relationship between radiographic NAFLD and brain volume as measured by MRI. The study demonstrated that NAFLD was linked to decreased TCBV even after accounting for known covariates. The estimated effect on brain age was greater for younger patients.

The current study provides evidence for a possible connection between NAFLD and brain health that may be more than just shared risk factors.  The study used a population of patients with well-studied cardiovascular parameters and may be important for generating hypotheses for further studies. It is limited by the reliance of radiographic rather than biopsy proven NAFLD or functional cognitive testing, homogenous nature of the population, and cross-sectional design limiting evaluation of causation.

Click to read the study, published in JAMA Neurology

Relevant Reading: Non-alcoholic fatty liver disease and cerebral small-vessel disease in cognitively normal individuals

RELATED REPORTS

Palliative care improves satisfaction in patients with progressive neurologic diseases and their caregivers

Dementia is associated with high rates of sleep-related breathing disorders

Wellness Check: Sleep

In-Depth [cross-sectional study]: This study is a cross-sectional analysis of the offspring cohort of the Framingham Heart Study which evaluated participants between 2002 and 2005. Participants were excluded if they were younger than 35 years (men) or 40 years (women), consumed more than 14 (men) or 7 (women) alcoholic beverages a week, were greater than 160 kgs, had established dementia, or if CT scans of the abdomen, or MRI of the brain were not available.

There were 766 participants included in the study, and 137 (17.9%) had CT evidence of NAFLD. NAFLD was linked to reduced TCBV after adjustment for known covariates (β [SE], –0.26 [0.11]; p = 0.02). Estimated for brain age loss was 7.3 years for participants under 60 years, 4.2 years for those aged 60-74, and 1.5 years for those 75 years of older.

Image: PD

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: cognitive impairmentdementianon-alcoholic fatty liver disease (NAFLD)
Previous Post

Erenumab linked to decreased episodic migraine frequency: The STRIVE trial

Next Post

Parents report greater optimism than oncologists about their child’s cancer prognosis

RelatedReports

Quick Take: Risk of rhabdomyolysis with donepezil compared with rivastigmine or galantamine
Chronic Disease

Palliative care improves satisfaction in patients with progressive neurologic diseases and their caregivers

March 28, 2023
Psychiatric conditions less likely to be granted physician-assisted suicide
Chronic Disease

Dementia is associated with high rates of sleep-related breathing disorders

March 20, 2023
Decline in adolescent sleep duration over past 20 years
Wellness

Wellness Check: Sleep

March 16, 2023
Myeloperoxidase upregulation in epileptogenesis seen on molecular imaging
Chronic Disease

The emergence of visual artistic creativity in frontotemporal dementia: a case-control study

March 7, 2023
Next Post
AAP supports limits on juice consumption in pediatric diet

Parents report greater optimism than oncologists about their child’s cancer prognosis

AAP reaffirms support for adolescents’ rights to confidential reproductive care

Multiple treatment trajectories exist in adolescent depression

Use of plant-based therapies and menopausal symptoms

Clinician denial of certain patient requests linked with decreased satisfaction

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Addition of fludrocortisone to hydrocortisone is beneficial in management of septic shock
  • Surveillance testing of staff at nursing facilities reduces resident COVID-19 mortality
  • Childhood maltreatment may cause mental health problems
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options