Tag: copd

Understanding the burden of health conditions in older adults in the U.S. is essential in addressing the healthcare demands of this patient population. This is of particular importance as the life expectancy in the U.S. continues to advance. In this retrospective cohort study, investigators analyzed data from 1998-2014 that...

Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval There is current debate surrounding the high cost of many medications, as many groups have voiced opposition to high prices while others have argued that high prices are justified by the costs required for...

Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease Chronic obstructive pulmonary disease (COPD) has become increasingly prevalent with broad morbidity. In the early stages of COPD, defined as GOLD (Global Initiative for Chronic Obstructive Pulmonary Disease) stages 1 and 2, many patients exhibit very mild or no apparent respiratory symptoms. Tiotropium...

1. Total airway mucin concentration was significantly elevated in current or former smokers with chronic bronchitis compared to non-smoker controls, and correlated with disease severity. 2. Concentrations of mucin subtypes MUC5AC and MUC5B were elevated relative to non-smoker controls, with a significantly higher MUC5AC-to-MUC5B ratio in smokers with mild-to-moderate COPD. Evidence...

1. Patients with mild or moderate COPD (chronic obstructive pulmonary disease) randomized to receive tiotropium had a significantly higher FEV1 (forced expiratory volume in 1 second) after bronchodilator use at 24 months since starting treatment than those who received a placebo inhaler. 2. Those who received daily inhaled tiotropium experienced...

1. There was no mortality benefit associated with receiving long-term oxygen supplementation in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation. 2. There were no significant differences between groups in terms of mortality, first hospitalization for any cause, or other measures of subjective quality...

Changes in moderate-to-vigorous physical activity among older adolescents While the Centers for Disease Control and Prevention recommend at least 60 minutes of moderate to vigorous physical activity (MVPA) for adolescents daily, data suggests that this goal is not being met. The purpose of this study was to examine determinants of...

1. A once-daily treatment of combined fluticasone furoate-vilanterol was associated with a significantly lower rate of exacerbations than usual care in patients with chronic obstructive pulmonary disease (COPD), without an increased risk of serious adverse events. 2. The trial used novel methodology to challenge the applicability of results in traditional...

  1. Indacaterol/glycopyrronium significantly reduced annual COPD exacerbation rates as compared to standard therapy with salmeterol/fluticasone. 2. The adverse events and deaths were similar across both groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Frequent COPD exacerbations are associated with reduced quality of life, mortality and increased hospital costs, thus regimens to reduce...

1. Expiratory central airway collapse is associated with chronic obstructive pulmonary disease and a poorer quality of life. 2. However, expiratory central airway collapse is not associated with all-cause mortality. Evidence Rating Level: 3 (Average) Study Rundown: It is well known that patients with chronic obstructive pulmonary disease (COPD) have a high...