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Filgotinib effectively induces and maintains clinical remission in patients with ulcerative colitis
1. At weeks 10 and 58, more patients in the filgotinib 200 mg group experienced clinical remission compared with the ...
Tag: Crohn’s Disease
Development of Anti-Drug Antibodies to Infliximab (Remicade®) and Adalimumab (Humira®) in Patients With Crohn’s Disease
1. Carriage of the HLA-DQA1*05 allele is significantly associated with the development of antibodies against anti-TNF agents. Evidence Rating Level: ...
Quick Take: Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor
In patients with Crohn’s disease (CD), endoscopic evidence of healing after treatment is associated with favorable outcomes. Anti-tumor necrosis factor ...
2 Minute Medicine Rewind August 26, 2019
Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis Diagnosing multiple sclerosis (MS) is challenging, ...
Quick Take: Efficacy and safety of biosimilar CT-P13 compared with originator infliximab in patients with active Crohn’s disease: an international, randomised, double-blind, phase 3 non-inferiority study
Anti-tumor necrosis factor (TNF) therapies are commonly used in the treatment of patients with moderate to severe Crohn’s disease. However, ...
Biosimilar to infliximab shows equivalent safety and efficacy for treating Crohn’s disease
1. The biosimilar to infliximab, CT-P13 was shown in this study to have equivalent efficacy to the anti tumor-necrosis factor ...
Recurrent Salmonella enterica Typhimurium infection disables host protection against intestinal inflammation [PreClinical]
1. Repeated gastrointestinal infections in mice, in this case Salmonella enterica Typhimurium (ST), caused intestinal tissue inflammation which escalated with ...
Anti-TNF agents and thiopurines are associated with a slight increase in lymphoma in IBD patients
1. In this retrospective cohort study, inflammatory bowel disease (IBD) patients on anti-tumor necrosis factor (TNF) agents or thiopurines had ...
Magnetic resonance enterography performs well in detecting active inflammation in pediatric inflammatory bowel disease
1. This systematic review and meta-analysis demonstrated the high diagnostic performance of magnetic resonance (MR) enterography in the diagnosis of ...
Ustekinumab linked with efficacy in treatment of Crohn’s disease: The UNITI-1 & 2, IM-UNITI trials
1. Ustekinumab achieved successful clinical induction in a greater proportion of patients with moderate to severe Crohn’s disease (CD) compared ...
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