Tag: dexamethasone

1. The use of intraoperative dexamethasone in infants undergoing elective cardiac surgery with cardiopulmonary bypass did not significantly reduce major complications or mortality compared to placebo. 2. While most outcomes were comparable between the two groups, mean blood glucose levels were higher in the dexamethasone group 24 hours post-surgery.  Evidence Rating...
1. Study findings suggest that early administration of intravenous dexamethasone during acute respiratory distress syndrome may decrease duration of mechanical ventilation and mortality rates. Evidence Level: 1 (Excellent) Acute respiratory distress syndrome (ARDS), characterized by acute hypoxemic respiratory failure and bilateral pulmonary infiltrates, is associated with significant mortality rates and currently have...
Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial 1. Study findings suggest that early administration of intravenous dexamethasone during acute respiratory distress syndrome may decrease duration of mechanical ventilation and mortality rates. Evidence Level: 1 (Excellent) Acute respiratory distress syndrome (ARDS), characterized by acute hypoxemic respiratory failure...
1. Approximately a quarter of multiple myeloma patients that had refractory disease despite treatment with a proteasome inhibitor, immunomodulatory agent, and daratumumab experienced treatment response with selinexor and dexamethasone. 2. Thrombocytopenia was a common adverse event in patients. Evidence Rating Level: 2 (Good)   Study Rundown: Relapse is common for multiple myeloma...
  Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults Acute sore throat is one of the most common complaints in patients that present to primary care facilities. Frequently, patients are treated unnecessarily with antibiotics, despite low risks of suppurative complications and limited symptomatic benefit....
1. This double-blinded, placebo-control trial found that, among patients with acute sore throat, those who received dexamethasone were no more likely than those who received placebo to have complete symptom resolution at 24 hours. 2. At 48 hours, more participants receiving dexamethasone had symptom resolution compared to those who received...
1. Use of dexamethasone prior to vaginal prolapse surgery for pelvic organ prolapse was associated with less postoperative nausea and vomiting. 2. Patients who received dexamethasone were more likely to pass postoperative voiding trials compared to those on placebo. Evidence Rating Level: 1 (Excellent)       Study Rundown: Vaginal reconstruction for pelvic organ prolapse...
1. Progression-free survival was improved by about 3 months with continuous lenalidomide-dexamethasone compared to standard melphalan-prednisone-thalidomide. 2. Overall survival was also better with continuous lenalidomide-dexamethasone compared to melphalan-prednisone-thalidomide. Evidence Rating Level: 1 (Excellent) Study Rundown: Multiple myeloma (MM) is a disease of plasma cells. Over proliferation of these antibody-producing...
Classics Series, Landmark Trials in Medicine
1. Of 125 patients with newly diagnosed immune thrombocytopenic purpura, 106 (85%) had an initial response to high-dose dexamethasone therapy 2. Half of the 106 patients with an initial response to high-dose dexamethasone had a sustained response after six months of follow-up Original Date of Publication: August 28, 2003 Study Rundown: This...
1. Both the 0.35mg and 0.7mg dexamethasone dosing led to a significant increase in visual acuity compared to sham. 2. Central retinal thickness, a measure of the extent macular edema, was decreased significantly in the 0.35mg and 0.7mg dexamethasone treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Diabetic macular edema (DME),...