Tag: dexamethasone

1. Time to recovery was lower in patients assigned to budesonide compared to usual care, meeting the superiority criteria. 2. Rate of hospitalizations or death was numerically lower in the inhaled budesonide group compared to usual care.  Evidence Rating Level: 1 (Excellent) Study Rundown: Systemic corticosteroids, such as dexamethasone, have been widely...

1. Daratumumab therapy addition to bortezomib, cyclophosphamide, and dexamethasone showed improved cancer response in patients with systemic immunoglobulin light-chain amyloidosis. 2. The daratumumab group presented with an increase in serious adverse events such as lymphopenia, cardiac failure, and infections. Evidence Rating Level: 1 (Excellent) Study Rundown: Immunoglobulin light-chain amyloidosis (AL) is a...

1. This phase III drug trial showed that dexamethasone does not significantly reduce risk of adverse events and death following major non-cardiac surgery. 2. Secondary safety outcomes were comparable between the dexamethasone and placebo groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Major surgery has potential major complications, such as shock, infection,...

1. Higher rates of treatment response were observed in patients receiving isatuximab with carfilzomib–dexamethasone than carfilzomib–dexamethasone alone. 2. Improved median progression-free survival and estimated survival rates two years after randomization in favor of the isatuximab group. Evidence Rating Level: 1 (Excellent) Study Rundown: Multiple myeloma (MM) remains an incurable hematologic malignancy, typically...

1. Adrenal incidentalomas patients with severely elevated cortisol levels following a dexamethasone suppression test were shown to have a three-time increase in the risk of mortality compared to patients without autonomous cortisol secretion. 2. The relationship between cortisol level and mortality was found to be linear until a cortisol concentration,...

1. Intraoperative dexamethasone was shown to be non-inferior to placebo for surgical-site infection incidence. 2. Intraoperative dexamethasone was shown to lower postoperative nausea and vomiting 24 hours after the surgery. Evidence Rating Level: 1 (Excellent) Study Rundown: Dexamethasone prevents postoperative nausea and vomiting; however, there are concerns regarding the increased risk of...