Tag: donepezil

1. Donepezil is associated with an elevated short-term risk of hospital admission for rhabdomyolysis compared to rivastigmine or galantamine for Alzheimer’s disease and dementia. Evidence Rating Level: 2 (Good) Regulatory agencies have issued a post-marketing surveillance warning regarding the risk of rhabdomyolysis with donepezil use, commonly used in managing symptoms of...
The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial 1. Selective serotonin reuptake inhibitors (SSRIs) are not associated with significant short-term reductions in depressive symptoms in the primary care setting, but reduce short-term anxiety and improve...
Classics Series, Landmark Trials in Medicine
Image: PD 1. High-dose vitamin E supplementation does not slow down progression to Alzheimer’s disease  2. Donepezil, a cholinesterase inhibitor, shows modest reductions in risk of progression to Alzheimer’s disease early in treatment Original Date of Publication: June 9, 2005 Study Rundown: Around 80% of people who meet criteria for amnestic mild cognitive...