Tag: emphysema

1. There was no mortality benefit associated with receiving long-term oxygen supplementation in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation. 2. There were no significant differences between groups in terms of mortality, first hospitalization for any cause, or other measures of subjective quality...
1. At 1 year, patients with severe emphysema who received bilateral endobronchial coils demonstrated modest improvements in expiratory flow rate and exercise tolerance. 2. The use of endobronchial coils was associated with higher rates of complications, including pneumothorax, pneumonia, and hemoptysis. Evidence Rating Level: 1 (Excellent) Study Rundown: Emphysema is one of...
Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: A randomized clinical trial Clostridium difficile infection (CDI) has become a major burden in healthcare and community settings, with limited treatment options available for patients with recurrent, refractory infections. Recently, fecal microbiota...
1. In a retrospective review of over 190 patients with primary lung cancers, patients with lower grade emphysema and airway-predominant disease as determined by pulmonary computed tomography had a significantly higher frequency of central lung cancers as compared to patients with severe emphysema. Evidence Rating Level: 3 (Average)        Study Rundown: Chronic...
1. The presence of emphysema-like lung detected on computed tomography (CT) scans was associated with increased all-cause mortality in patients without obstructive lung disease. 2. This link was also associated with patient smoking status. Evidence Rating Level: 2 (Good) Study Rundown: Although obstructive lung diseases like emphysema are typically associated with smoking,...

Patient Basics: Emphysema

Originally published by Harvard Health.   What Is It? Emphysema is a respiratory disease. In this condition, millions of the lungs' tiny air sacs (alveoli) stretch out of shape or rupture. As these thin, fragile air sacs become damaged or destroyed, the lungs lose their natural elasticity. They become unable to empty easily. Emphysema...
Classics Series, Landmark Trials in Medicine
1. The combination of salmeterol and fluticasone did not significantly reduce all-cause mortality in patients with chronic pulmonary obstructive disease (COPD) 2. When compared with salmeterol alone, fluticasone alone, and placebo, combination therapy significantly reduced the risk of exacerbations and the need for systemic corticosteroids during exacerbations Original Date of Publication:...
Classics Series, Landmark Trials in Medicine
Image: PD 1. Lung-volume-reduction surgery significantly improves exercise capacity, but not overall survival, in patients with emphysema when compared with medical therapy 2. Post hoc subgroup analyses showed that in patients with upper-lobe emphysema and low baseline exercise capacity, lung-volume-reduction surgery significantly decreased mortality compared to medical therapy Original Date of Publication:...