Tag: fracture

1. The use of proton pump inhibitors (PPIs) in a large pediatric cohort resulted in a small but statistically significant increase in fracture risk compared to children who were not using PPIs. Evidence Rating Level: 2 (Good) Proton pump inhibitors (PPIs) are the primary treatment for gastric acid-related disorders in children, despite...
1. The cathepsin K inhibitor odanacatib reduced the risk of fracture but was associated with significantly increased risk of cardiovascular events, specifically stroke, in postmenopausal women with osteoporosis compared to placebo. Evidence Rating Level: 1 (Excellent) Odanacatib, a cathepsin K inhibitor, reduces bone resorption without compromising bone formation, with further findings suggesting...
1. Canagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, significantly reduced the risk of the primary composite outcome of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke in patients with type 2 diabetes when compared to placebo. 2. Patients treated with canagliflozin experienced significantly higher rates of amputation, fracture, and...
1. In this prospective cohort study, measurements of orthostatic hypotension within one minute of standing were associated with higher odds of history of dizziness and higher rates of fracture, syncope, and death. 2. Contrary to existing belief and clinical practice, measurements done after one minute were not associated with history...
1. In post-hoc analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), use of thiazide diuretic chlorthalidone in patients with hypertension was associated with lower risk of fracture hospitalizations compared to calcium channel blocker (amlodipine) and ACE-inhibitor (lisinopril). 2. This further adds to the evidence that...
1. Among older adult patients with ankle fractures, close contact casting resulted in similar functional outcomes at 6 months compared to surgery, suggesting casting as appropriate treatment for such patients. 2. There were no significant differences in secondary outcomes between these two groups in terms of quality of life, pain,...
1. In a retrospective cohort study of Medicare beneficiaries, there was no overall change in prescribing patterns of drugs that increased or decreased fracture risk before and after fragility fractures. 2. There was a subset of patients for whom the prescribing of high risk medications decreased, but this was matched...
1. In this retrospective cohort study, parathyroidectomy improved bone mineral density and reduced the overall fracture rate more than observation or bisphosphonates in patients with primary hyperparathyroidism. 2. Bisphosphonates were associated with a higher fracture rate than observation alone. Evidence Rating Level: 2 (Good) Study Rundown: Primary hyperparathyroidism (PHPT) is a common...
1. In a retrospective review of over 7600 patients who previously underwent hematopoietic stem-cell transplantation, there was a significantly increased incidence of fractures compared to the United States general population. Evidence Rating Level: 3 (Average) Study Rundown: The use of hematopoietic stem-cell transplantation (HSCTs) has significantly improved survival in patients with multiple myeloma and...
1. There were no overall statistically significant differences between patients with humeral fractures treated with surgical treatment and those treated with nonsurgical treatment after adjustment for smoking status or clustering by center. 2. Surgical patients (24%) experienced a complication slightly more often than nonsurgical patients (18%) but the difference...