Tag: hepatitis C

1. The rate of hepatitis C virus (HCV) transmission from nucleic acid amplification testing (NAT)-negative donor hearts is low, and survival rates in patients with donor-derived HCV are high. Evidence Rating Level: 2 (Good) While there have been considerable advances in heart transplantation, more and more patients are becoming reliant on...

Association of prehospital plasma transfusion with survival in trauma patients with hemorrhagic shock when transport times are longer than 20 minutes: A post-hoc analysis of the PAMPer and COMBAT clinical trials 1. Prehospital plasma transfusion is associated with increased survival in the setting of hemorrhagic shock, particularly with longer transport...

The opioid epidemic has been associated with rising hepatitis C virus (HCV) infection incidence in North America among those who inject drugs. While opioid agonist therapy may reduce HCV infection risk, the role of dosage of such therapy on this association is unclear. Given an increasing focus on global...

Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study Early evidence has suggested a strong association between HIV viral load and the risk of transmission to an HIV-negative partner, as well...

1. HCV-naive patients in need of heart or lung transplants who received organs from HCV-positive donors and were treated with sofobuvir-velpatasvir demonstrated intact graft function with undetectable viral loads during post-surgical follow up. 2. No treatment-related serious adverse effects were noted in the study population. Evidence Rating Level: 2 (Good) Study Rundown:...

1. All 20 patients included in the study were cured of HCV following antiviral therapy. 2. Similar eGFR scores were found between nontransplant and transplant patients.  Evidence Rating Level: 2 (Good) Study Rundown: The wait for kidney transplantation remains long, exceeding five years in many areas of the United States. While kidney...

1. Use of HCV-infected kidneys increased patients’ quality-adjusted life expectancy. 2. Lower costs were associated with HCV-infected kidneys compared to transplanting HCV-uninfected kidneys to HCV-positive patients. Evidence Rating Level: 2 (Good) Study Rundown: Organ availability for transplantation is limited; therefore, for patients with end stage renal disease (ESRD), hemodialysis is often the...

1. In this retrospective study, only a fraction of infants receiving well-child care at the study institution were screened for hepatitis C, despite being born to mothers with a known history of hepatitis C virus infection. 2. Opioid use in mothers was the only factor positively associated with practitioners accurately...

1. No HCV infection was detected in patients receiving HCV-infected kidneys 12 weeks following treatment. 2. No antiviral treatment-related complications occurred recipients of HCV-infected kidneys. Evidence Rating Level: 2 (Good) Study Rundown: Kidney failure and end-stage kidney disease result in significant morbidity and mortality. While kidney transplant is a viable solution for...

1. Both 8 and 12-week regimens of glecaprevir-pibrentasvir were highly efficacious in producing sustained virologic response in patients infected with hepatitis C virus (HCV) genotypes 1 and 3, and the 8-week treatment duration was noninferior to 12-week duration. 2. Similar low rates of serious adverse events or clinically significant laboratory...