Tag: herpes

1. In this randomized controlled trial, pritelivir was effective in reducing the number of HSV-2 positive swabs, total days with herpetic lesions, and the number of days of reported pain when compared to valacyclovir. 2. Though this trial was put on clinical hold by the FDA due to dermatological side-effects...
  1. In this double-blinded randomized controlled study, women randomized to apply intracoital vaginal tenofovir gel were significantly less likely to seroconvert to herpes simplex virus type 2 (HSV-2) compared to women who applied identical-appearing placebo gel. 2. Tenofovir has had mixed results in preventing HIV transmission when used in a topical...
Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults Herpes zoster continues to be a menacing disease especially for patients who are 50 years of age or older, resulting in more frequent post infectious complications in this population including post herpetic neuralgia. The current live-attenuated vaccine for herpes...
1. Pharmaceutical inhibition of lysine-specific demethylase 1 (LSD1) reduced primary infection of herpes simplex virus (HSV), shedding, and reactivation in multiple animal models. 2. Inhibition of LSD1, a required histone demethylase, resulted in lasting epigenetic suppression of the viral genome, which was associated with decreased infection activity. Evidence Rating Level:...
1. Daily oral pre-exposure prophylaxis (PrEP) with tenofovir alone or in combination with emtricitabine in heterosexual individuals in high-risk populations was associated with a reduced risk of acquiring herpes simplex 2 (HSV-2).  Evidence Rating Level: 1 (Excellent) Study Rundown: PrEP with tenofovir with or without emtricitabine has been associated with protection...
Image: PD/HSV-2 In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Calcium Density of Coronary Artery Plaque and Risk of Incident Cardiovascular Events Coronary artery calcium (CAC) is measured by computed tomography (CT) and can be of strong predictive value for...
Image: PD 1. The incidence of herpes zoster among United States adults has been increasing since 1992 2. However, the annual rate of increase in herpes zoster incidence has not changed significantly since the introduction of routine varicella vaccinations in children Evidence Rating Level: 2 (Good) Study Rundown: In 1996, a universal varicella...
Jan 20th - HSV-1 infection in young women is more likely to be genital than oral. Image: PD 1. Young women (18-22) are more likely to acquire HSV-1 infection than HSV-2.   2. HSV-1 infection in young women is more likely to be genital than oral. 3. HSV-2 infection is more likely in non-Hispanic...