LSD1 inhibition reduces herpesvirus infection and recurrence in animals [PreClinical]
1. Pharmaceutical inhibition of lysine-specific demethylase 1 (LSD1) reduced primary infection of herpes simplex virus (HSV), shedding, and reactivation in...
![Tumor-specific mutant antigens are potential targets for cancer therapy [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2014/12/mouse-e1417555547919-350x250.jpg)
Tumor-specific mutant antigens are potential targets for cancer therapy [PreClinical]
1. Following checkpoint blockade therapy (CBT) in a mouse sarcoma model, two dominant tumor-specific mutant antigen (TSMA) targets of CD8+...
Genetically engineered lymphocytes inhibit Hepatitis C virus replication in vitro [PreClinical]
1. Activated suicide gene modified lymphocytes (SGMLs) inhibit Hepatitis C virus (HCV) replication multiple in vitro models of infection. 2....
Rapamycin inhibits intestinal tumor formation and growth [PreClinical]
1. Rapamycin (rapa) inhibited tumor initiation in Adenomatous polyposis coli gene (Apc)-deficient mouse intestinal epithelial cells, and enhanced survival in...