Tag: hydroxyurea

1. Children with sickle cell disease who received the maximum tolerated dose of hydroxyurea had higher concentrations of hemoglobin and fetal hemoglobin compared to those who received the fixed standard dose. 2. Patients in the dose escalation group also had fewer adverse events and required fewer key medical interventions than...
1. Children with sickle cell disease who received the maximum tolerated dose of hydroxyurea had higher concentrations of hemoglobin and fetal hemoglobin compared to those who received the fixed standard dose. 2. Patients in the dose escalation group also had fewer adverse events and required fewer key medical interventions than...
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 1. SARS-CoV-2 appears to have the longest surface viability on plastic and stainless steel compared to in aerosol, copper, or cardboard with detection of viable virus up to 72 hours post application on plastic. 2. Stability of SARS-CoV-2 appears to similar...
1. Among sub-Saharan African children with sickle cell anemia (SCA) treated with hydroxyurea, 5.1% experienced dose-limiting toxic events, well below the protocol-specified allowable rate of 30%. 2. Compared to pretreatment rates, children treated with hydroxyurea had significantly reduced rates of vaso-occlusive pain, infection, malaria, transfusion, and death after one year. Evidence...
1. Data analysis from the BABY HUG trial comparing immunologic function in children with sickle cell disease treated with hydroxurea versus placebo revealed that while absolute lymphocyte counts were lower in hydroxyurea-treated children, these numbers were still within the range of normal for healthy children. 2. By the end of...