Novel inhibitory antibody, MAR001, lowers triglycerides and remnant cholesterol in humans
1. ANGPTL4 inhibition decreased triglyceride and remnant cholesterol levels by over 50%. 2. MAR001 was well-tolerated with no significant treatment-related ...
Tag: hypercholesterolemia
No known association between PCSK9 gene variants and risk of heart failure
1. There was no association detected between PCSK9 gene variants and alterations in cardiac morphology. 2. The odds of having ...
Combination-drug therapy and earlier detection recommended to improve outcomes in heterozygous familial hypercholesterolemia
1. A significantly greater proportion of patients receiving 2-3 lipid lowering medications achieved LDL-cholesterol targets compared to those receiving monotherapy. ...
Evinacumab may be effective in reducing lipid levels in patients with refractory hypercholesterolemia
1. After 16 weeks of treatment, patients who received evinacumab had decreases in low density lipoprotein (LDL) of up to ...
Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring
1. Children of mothers with diabetes are more likely to develop cardiovascular disease. Evidence Rating Level: 2 (Good) The prevalence of ...
