Tag: hypertrophic cardiomyopathy

1. Truncating mutations in cardiac myosin-binding protein C (MYBPC3) are a common genetic cause of hypertrophic cardiomyopathy. 2. Haploinsufficiency of MYBPC3 results in cardiomyocyte hypercontractility and impaired relaxation by altering dynamic myosin configurations. Evidence Rating Level: 2 Study Rundown: Hypertrophic cardiomyopathy (HCM) is a disease that causes thickening of the heart...