Tag: infectious diseases

The trial to reduce antimicrobial use in nursing home residents with Alzheimer disease and other dementias (TRAIN-AD) 1. In a large trial, a multi-component interventional program did not reduce antimicrobial use amongst people with advanced dementia living in nursing homes. Evidence Rating Level: 1 (Excellent) Antimicrobials are commonly prescribed to individuals within...
1. Among a group of primary school children in Tanzania, a combination intervention aimed at enhancing handwashing had no effect on soil-transmitted helminth infection. Evidence Rating Level: 1 (Excellent) Soiled-transmitted helminth (STH) infections are frequent amongst school children in low- and middle-income countries. It represents significant morbidity as it is associated...
1. The administration of probiotics to high-risk inpatients receiving antibiotics identified by computerized clinical decision support was not shown to decrease the incidence of Clostridioides difficile infection. Evidence Level Rating: 2 (Good) Clostridioides difficile infection (CDI) is prevalent in the U.S. and produces substantial morbidity and mortality. Meta-analyses have suggested that...
Cardiovascular safety of hydroxychloroquine in veterans with rheumatoid arthritis 1. Among a large, matched cohort of veterans with rheumatoid arthritis, initiation of hydroxychloroquine was not associated with a higher risk of adverse cardiovascular events or death. Evidence Rating Level: 1 (Excellent) In anecdotal case reports, hydroxychloroquine (HCQ) has been reported to prolong...
Association of intensive vs standard blood pressure control with magnetic resonance imaging biomarkers of Alzheimer's Disease 1. Intensive treatment of blood pressure resulted in small but statistically significant greater decline in hippocampal volume compared to standard treatment. 2. No significant differences between treatment groups in other Alzheimer’s disease biomarkers. Evidence Rating Level:...
1. Among older adults with urinary tract infections, antibiotic prophylaxis was associated with an increased risk of ED visit or hospitalization for UTI, sepsis, or bacteremia. Evidence Level Rating: 2 (Good) Urinary tract infections (UTI) are the most common bacterial infections prompting the utilization of health care services. They exert a...