Tag: influenza

1. The antiviral agent baloxavir (baloxavir marboxil) decreased duration of influenza symptoms significantly more than in patients treated with either placebo or oseltamivir. 2. Baloxavir reduced viral load significantly more 1 day after initiation of treatment than placebo or oseltamivir. Evidence Rating Level: 1 (Excellent)      Study Rundown: Emergence of viral strains resistant...

1. The quadrivalent recombinant influenza vaccine (RIV4) was noninferior when compared with the quadrivalent inactivated influenza vaccine (IIV4) for immunogenicity. Evidence Rating Level: 1 (Excellent) Study Rundown:  Seasonal influenza vaccines have recently been transitioned to a quadrivalent, recombinant formulation to provide broadened protection against 2 antigenically distinct influenza type B lineages...

1. No increased risk of incident epilepsy was seen among children who received influenza vaccination during the 2009-2010 influenza season in Norway. Evidence Rating Level: 2 (Good) Study Rundown: Previous studies suggest associations between febrile seizures and influenza infection, complex febrile seizures and epilepsy, and seizures (particularly febrile) and vaccination (including...

1. In a self-controlled case series, patients were observed to have increased incidence of hospital admissions for acute myocardial infarction (MI) within seven-days of respiratory virus detection.   2. Cases of MI hospitalization after respiratory virus detection trended towards higher rates in older adults and patients with a confirmed influenza...

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension  Early resuscitation protocols have been shown to reduce sepsis mortality. However, studies have been primarily conducted in high-income, high-resource countries, with little research in low- and middle-income countries. In this randomized controlled trial, 212 adults...

1. Compared to traditional rapid influenza diagnostic tests (RIDTs), digital immunoassays (DIAs), and rapid nucleic acid amplification tests (NAATs) had significantly higher sensitivities for influenza A and B in both adults and children, with specificities that were equally high. 2. The clinical impact and economic impact of DIAs and NAATs...

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia Preterm preeclampsia is a potential complication of pregnancy that can cause maternal or perinatal death. In this double-blind, randomized controlled trial, low-dose aspirin was investigated for its effect on reducing the risk of preterm preeclampsia, as compared to placebo...

1. Older adults receiving recombinant influenza vaccine experienced fewer cases of polymerase chain reaction (PCR) confirmed influenza-like illness than patients receiving a similar inactivated influenza vaccine. 2. Greater efficacy of the recombinant vaccine was due to greater efficacy against the predominant influenza A strain of the 2014-2015 season, as efficacy...

  Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults Obesity is known to exacerbate age-related decline in physical function. In older adults, associated reductions in muscle and bone mass place patients at risk of frailty. Exercise has been shown to improve physical functioning in older adults and reduce...

1. Estimated influenza vaccine effectiveness (VE) was 65% against laboratory-confirmed influenza-associated deaths among children. 2. Vaccine effectiveness was lower at 51% for children with underlying medication conditions, though the protection remained significant. Evidence Rating Level: 2 (Good) Study Rundown: Data on influenza-associated deaths in children indicate that most deaths occur in unvaccinated children....