Tag: Kawasaki disease

1. In this single-center study of children hospitalized with MIS-C, most had complete recovery of cardiac function. 2. While most markers of inflammation normalized rapidly, the proportion of double-negative T-cells (DNTs) remained elevated in nearly all patients at the 4 to 9 month follow up. Evidence Rating Level: 2 (Good) Study...
1. Presentation with shock in the setting of multisystem inflammatory syndrome in children (MIS-C) was associated with worse outcomes 2. Shorter duration of MIS-C symptoms prior to hospital admission was associated with poor outcomes Evidence Rating Level: 2 (Good) Study Rundown: MIS-C is a complication of SARS-CoV-2 that has led to severe...
1. Pediatric patients during the COVID-19 pandemic present with a wide range of cardiac manifestations that require early detection and treatment. Evidence Rating Level: 2 (Good) The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has resulted in increased hyperinflammatory presentations in otherwise healthy children. This international, multi-center, retrospective chart...
1. Severe acute respiratory syndrome coronavirus 2 infection increases the rate of Kawasaki disease in children. 2. Individuals with severe Kawasaki disease were more likely to have myocarditis, require combination therapy with inotrope treatment, and require admission to the intensive care unit. Evidence Rating Level: 2 (Good) Study Rundown: Viral disease is...
1. Severe acute respiratory syndrome coronavirus 2 infection increases the rate of Kawasaki disease in children. 2. Individuals with severe Kawasaki disease were more likely to have myocarditis, require combination therapy with inotrope treatment, and require admission to the intensive care unit. Evidence Rating Level: 2 (Good) Study Rundown: Viral disease is...
1. Findings from a cohort in Bergamo, Italy indicate a roughly 30-fold increase in the incidence of Kawasaki-like disease associated with the SARS-CoV-2 outbreak. 2. Pediatric patients diagnosed with Kawasaki-like disease post COVID-19 were more likely to have a more severe form of the disease, and had higher rates of...
1. Findings from a cohort in Bergamo, Italy indicate a roughly 30-fold increase in the incidence of Kawasaki-like disease associated with the SARS-CoV-2 outbreak. 2. Pediatric patients diagnosed with Kawasaki-like disease post COVID-19 were more likely to have a more severe form of the disease, and had higher rates of...
Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study 1. In three separate models, it was found that the combination of decreased health care access, food availability, and the economic impacts (both intentional and unintentional) of...
1. In this meta-analysis of available comparative studies, use of corticosteroids as adjunctive therapy to IVIG and aspirin in Kawasaki disease was associated with a lower risk of coronary artery abnormality and earlier defervescence compared to IVIG/ASA alone. 2. In subgroup analysis the earlier timing of steroid therapy had lower...
1. Results of this retrospective study revealed that children diagnosed with Kawasaki disease often have a concurrent respiratory viral infection detectable by polymerase chain reaction (PCR). 2. Concurrent detection of a respiratory virus by PCR does not appear to be linked to the clinical presentation or outcomes of children with...