• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Infectious Disease

Dual therapy with infliximab and IVIG in children with multi-system inflammatory syndrome

byAlex Gipsman, MDandAbdullah Haroon
November 25, 2021
in Infectious Disease, Pediatrics, Rheumatology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In a single center retrospective cohort study of children with multi-system inflammatory syndrome (MIS-C), children treated with IVIG and infliximab had better clinical outcomes than those treated with IVIG alone.

2. Children who received infliximab had better cardiac outcomes, had a shorter ICU stay, and showed more rapid decline in inflammation.

Evidence level: 2 (good)

Study Rundown: One clinical sequalae of pediatric COVID-19 infection is the development of multi-system inflammatory syndrome in children (MIS-C), a highly inflammatory state that can lead to end-organ damage and even death. The use of intravenous globulin (IVIG) is the standard of care in treating these patients, but the addition of biologic therapies has not been well-studied. This single-center retrospective study from Colorado aimed to assess the value of dual therapy with infliximab and IVIG in improving clinical outcomes in MIS-C compared to IVIG alone. Results showed that fewer patients on dual therapy required additional medical therapy 24 hours later (31%) than with single therapy (65%); patients’ stay in the ICU was decreased by 2 days; and fewer patients developed left ventricular dysfunction (LV) with dual therapy (3%) versus 19% with IVIG alone. A major strength of this study is that it includes patients who met the CDC criteria for the disease, allowing it to be easily replicated at other centers. However, the retrospective study design is a major limitation in ruling out contributing confounding factors, and randomized controlled trials are still necessary. Overall, this study indicates that improved clinical outcomes may be associated with the addition of infliximab to IVIG in the treatment of MIS-C.

Click here to read the original article

Relevant reading: SARS-CoV-2-associated multisystem inflammatory syndrome in children: clinical manifestation and the role of infliximab treatment

RELATED REPORTS

Worsening kidney function observed following SARS-CoV-2 infection in children

Hospital-onset antimicrobial resistance increased during COVID-19 pandemic

Increased blood–urea–nitrogen-to-albumin ratio associated with increased mortality in coronavirus disease

In-depth [retrospective cohort]: This is a single center retrospective cohort study from Children’s Hospital Colorado analyzing data between April 1 and February 28, 2021. During this time, 72 children were diagnosed with MIS-C in accordance with the CDC criteria. The primary variable of interest was the need for additional immunomodulatory therapy 24 hours after initial therapy. Secondary outcomes included length of ICU stay, new or worsening LV dysfunction, need for diuretics, and decreased inflammation. Children treated with dual therapy of IVIG (2 g/kg given over 10-12 to 20-24 hrs) and Infliximab (10 mg/kg) compared to IVIG alone less frequently required additional therapy (16 of 52 [31%] vs. 13 of 20 [65%]); had a lower rate of new or worsening LV dysfunction (3% vs. 19%); and had a more pronounced anti-inflammatory response as measured by decline in CRP levels (-70% vs. -5%) 48 hours post-treatment. No significant difference was found in the length of hospital stay, time to fever cessation, vasoactive medication duration, or the need for diuretics. Infliximab-followed-by-IVIG had better outcomes in the need for diuretics compared to IVIG-followed-by-infliximab (29% vs. 75%) and led to a sharper decline in CRP levels (-54% vs. -16%) 24 hours post-treatment. However, no differences in cardiac outcomes were found for either treatment sequence.

Image: PD ©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: COVID-19Kawasaki diseasemultisystem inflammatory syndrome in children (MIS-C)
Previous Post

Wellness Check: Addictions

Next Post

#VisualAbstract Intensive chemotherapy is associated with better long-term survival in older patients with acute myeloid leukemia

RelatedReports

Being overweight and obese associated with increased incidence of chronic kidney disease
Chronic Disease

Worsening kidney function observed following SARS-CoV-2 infection in children

May 23, 2025
High risk of complications, but low mortality among children with MRSA bacteremia
Infectious Disease

Hospital-onset antimicrobial resistance increased during COVID-19 pandemic

April 28, 2025
Novel coronavirus identified from patients with pneumonia in Wuhan, China
Hematology

Increased blood–urea–nitrogen-to-albumin ratio associated with increased mortality in coronavirus disease

February 10, 2025
American Academy of Pediatrics recommends standards for adverse event disclosures
Weekly Rewinds

2 Minute Medicine Rewind February 10, 2025

February 10, 2025
Next Post
#VisualAbstract Intensive chemotherapy is associated with better long-term survival in older patients with acute myeloid leukemia

#VisualAbstract Intensive chemotherapy is associated with better long-term survival in older patients with acute myeloid leukemia

Equivalent efficacy of Paclitaxel or Irinotecan for advanced gastric cancer

Postoperative chemotherapy in chemosensitive patients undergoing surgical treatment of gastric cancer may prolong survival

Adalimumab aids in control of noninfectious uveitis

Automated pupillometry may be helpful in opioid agonist therapy dosing for opioid use disorder

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Approved label populations may be broader than trial populations for new drugs
  • Abridge drafts pediatric notes so physicians stay with the kids, not the keyboard
  • AAV gene therapy shows durable benefit in hemophilia B
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.