Tag: COVID-19

1. Among patients hospitalized with severe COVID-19 and hyperinflammation, treatment using the anti-interleukin-1β antibody canakinumab, compared with placebo, did not significantly increase the likelihood of survival without invasive mechanical ventilation at day 29. 2. These findings for canakinumab vs placebo were also consistent for the secondary outcome of COVID-19-related mortality...
1. In this single-center study of children hospitalized with MIS-C, most had complete recovery of cardiac function. 2. While most markers of inflammation normalized rapidly, the proportion of double-negative T-cells (DNTs) remained elevated in nearly all patients at the 4 to 9 month follow up. Evidence Rating Level: 2 (Good) Study...
1. The second wave of the COVID-19 pandemic in Canada was associated with increased depression, anxiety, and distress as compared to pre-pandemic rates. 2. As compared to the first wave of the COVID-19 pandemic, during the second wave individuals were more likely to engage in audiovisual media and less likely...
1. Levels of antibodies against the trimeric spike protein and receptor-binding domain were 36- and 77-fold higher in the BNT162b2 group compared to control. 2. There were no vaccine-related serious adverse events. Evidence Rating Level: 1 (Excellent)  Study Rundown: Current research on COVID-19 vaccination has revolved around a homologous dosing schedule (administering...
2 Minute Medicine is pleased to announce that we are launching Wellness Check, a new series dedicated to exploring new research evidence focused on wellness. Each week, we will report on articles examining different aspects of wellness, including (but not limited to) nutrition, sleep, reproductive health, substance use and...
1. After receiving the BNT162b2 SARS-CoV-2 vaccine, fewer cancer patients demonstrated seropositivity for COVID antibodies compared to age-matched healthy controls, but those that were seropositive had comparable titers to healthy controls. 2. The COVID vaccine was found to have an acceptable safety profile amongst cancer patients currently on treatment, with...
1. Health care assistants and nurses were at the highest risk of contracting SARS-CoV-2 among healthcare professionals early in the COVID-19 pandemic in Italy. 2. Healthcare workers employed in operational units that may result in prolonged exposure to SARS-CoV-2 patients, such as internal medicine and related subspecialties, were at higher...
1. Very high risk individuals that qualified for shielding interventions from COVID-19 were still at elevated risk for developing a severe infection. 2. Recent hospital exposures were the greatest risk factor for developing a case of severe COVID-19, among patients eligible for shielding interventions. Evidence Rating Level: 3 (Average) Towards the beginning...
1. The incidence of chilblains increased during the COVID-19 pandemic, but chilblains cases were only weakly associated with COVID-19 infection, with only 2.0% of patients testing positive for COVID-19. Evidence Rating Level: 2 (Good) Chilblains refer to lesions of the skin related to inflammation from cold, damp conditions. During the start...