Tag: meningitis

1. In this retrospective cohort study, infants with a history of fever but without fever on presentation to the hospital or subsequent fever while hospitalized were significantly less likely to have a serious bacterial infection (SBI) as compared to infants that were febrile on presentation. 2. Among patients with a...
A Bivalent Meningococcal B Vaccine in Adolescents and Young Adults A vaccine against Neisseria meningitidis serotype B is needed, as current polysaccharide-based vaccines do not cover this serotype. A bivalent vaccine, MenB-FHbp, containing factor H-binding protein variants has been licensed in the US, however, large assessment of its coverage and...
1. Healthy adolescents and young adults treated with the Neisseria meningitidis vaccine MenB-FHbp had increased bactericidal antibody responses (hSBA titer) compared to those treated with control vaccines. 2. More localized injection-site reactions occurred among patients treated with the meningococcal B vaccine compared to control vaccines. Evidence Rating Level: 2 (Good) Study...
1. The overall effectiveness of the meningococcal conjugate vaccine between 0 and 8 years post-vaccination was 69%. 2. The vaccine effectiveness (VE) was 79% at <1 year from vaccination, 69% at 1 to 3 years from vaccination, and 61% at 3 to 8 years from vaccination. Evidence Rating Level: 3 (Fair) Study...
1. In response to a meningococcal B outbreak at a US university in 2013 and 2014, the FDA approved the use of a recombinant meningoccal B vaccine (4CMenB) before licensure. 2. Among a sample of students who revived two doses of the 4CMenB vaccine, nearly one-third were found to be...
Originally published by Harvard Health. What Is It? Meningitis is an inflammation of coverings (meninges) of the brain and spinal cord. Most often it is caused by a viral or bacterial infection. Other infectious agents such as fungi can also cause meningitis. Rarer causes of meningitis include atypical drug reactions and...
1. N. meningitidis is a bacterium responsible for meningitis, bacteremia, and pneumonia, with potentially lethal and long term sequelae. 2. The American Academy of Pediatrics (AAP) has adjusted its vaccination guidelines to include two newly licensed conjugate vaccines, Hib-MenCY-TT and MenACWY-CRM, in an effort to address immunization of younger children...
1. For patients with cryptococcal meningitis and AIDS not previously treated with antiretrovirals, survival was better in the group starting antiretrovirals 5 weeks after diagnosis (delayed) vs. the group starting antiretrovirals 1 week after diagnosis (early).  Evidence Rating Level: 1 (Excellent)  Study Rundown: Cryptococcal infection begins in the lungs, but often...
Image: PD  In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear Arthroscopic partial meniscectomy is the most common orthopedic procedure in the US with an annual direct medical cost estimated...
Image: PD 1. People living with HIV/AIDS had a 10 times higher relative risk of developing invasive meningococcal disease.  Evidence Rating Level: 4 (Below Average)  Study Rundown: Human immunodeficiency virus (HIV), the infectious agent responsible for acquired immunodeficiency syndrome (AIDS), leads to decreased immunity and increased susceptibility of a multitude of opportunistic...