Tag: metoprolol

Classics Series, Landmark Trials in Medicine
1. The POISE trial was a randomized controlled trial exploring the effect of perioperative beta-blockers on cardiac death, nonfatal myocardial infarctions, and nonfatal cardiac arrest. 2. Perioperative oral extended-release metoprolol was found to reduce the risk of nonfatal myocardial infarction, while increasing the risk of stroke and mortality when compared...
1. In this double-blind randomized trial of COPD patients without previous indication for beta blocker therapy, treatment with extended-release beta-blockers failed to generate improved health outcomes versus placebo. No significant between-group difference was found in the median time until the first exacerbation of COPD. 2. Patients in the metoprolol group...
1. In this double-blind randomized trial of COPD patients without previous indication for beta blocker therapy, treatment with extended-release beta-blockers failed to generate improved health outcomes versus placebo. No significant between-group difference was found in the median time until the first exacerbation of COPD. 2. Patients in the metoprolol group...
Image: PD 1. Adding early metoprolol does not further decrease the risk of death post-MI compared to conventional fibrinolytic therapy alone. 2. Use of early metoprolol decreases the risk of reinfarction and ventricular fibrillation, but increases the risk of cardiogenic shock. 3. Adding clopidogrel to aspirin decreases the combined risk of death,...
Image: CC/L. academia 1. In patients with symptomatic heart failure and reduced ejection fraction, the addition of metoprolol to standard therapy reduced all-cause mortality by 34% compared to placebo. 2. Similar findings were reported in the CIBIS-II trial. Study Rundown: The findings of the MERIT-HF trial demonstrated that adding metoprolol controlled release/extended release...