Tag: Parkinson’s Disease

1. During an 80-week trial period of patient’s with early Parkinson’s disease (PD), there was no difference in the severity of symptoms between patients treated with levodopa-carbidopa for all 80 weeks (early-start group) versus those treated with levodopa-carbidopa for the second 40 weeks (delayed-start group). 2. There was no significant...

1. In this phase-2 randomized controlled trial, high-intensity treadmill exercise was associated with lower mean changes in the Unified Parkinson’s Disease Rating Scale motor score. 2. Adverse musculoskeletal events were not severe in the high-intensity exercise group. Evidence Rating Level: 2 (Good) Study Rundown: Parkinson disease is a progressive neurodegenerative disorder that...

1. Creatine monohydrate was not shown to improve or worsen clinical outcomes of Parkinson disease over a 5-year follow-up period. 2. No significant differences in benefits, adverse effects, laboratory values, or BMI were detected in the creatine group when compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Parkinson disease is...

1. Diffusion tensor imaging (DTI) of marmoset brains following chemically-induced Parkinsonism showed an increase in nigrostriatial diffusivity with a loss of corresponding fiber tracts as compared to controls, indicating a potential future role for imaging in the diagnosis of Parkinson’s disease. Evidence Rating Level: 3 (Average) Study Rundown: In Parkinson’s disease...

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans Sickle cell trait (SCT), inheritance of a single copy of the sickle hemoglobin mutation, affects 1 in 12...

Originally published by Harvard Health. What Is It? Parkinson's disease (PD) is a disease of the central nervous system. It causes problems with body motions, including: Tremor (shakiness) Rigidity (muscle stiffness) Slowed body movements Unstable posture Difficulty walking PD develops when certain nerve cells (neurons) in the brain die. These are neurons that produce a chemical called dopamine....