Tag: pcos

1. In mouse models of polycystic ovarian syndrome (PCOS), elevated adiponectin levels ameliorated metabolic dysfunction. 2. However, adiponectin was unable to completely restore reproductive function. Evidence Rating Level: 3 (Fair) Study Rundown: PCOS is the most common disorder affecting metabolism and reproduction in females. Patients with this syndrome have an elevated...
Classics Series, Landmark Trials in Medicine
1. Women with polycystic ovary syndrome (PCOS) randomized to receive letrozole had more live births than women randomized to clomiphene (27.5% vs. 19.1%, p=0.007). 2. Cumulative ovulation rates were higher in women on letrozole compared to those on clomiphene (61.7% vs. 48.3%, p<0.001). Original Date of Publication: July 2014 Study Rundown: Polycystic...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome Polycystic ovary syndrome (PCOS) affects 5 to 10 percent of reproductive age women and is the major cause of anovulatory infertility. Clomiphene,...
1. Letrozole, an aromatase inhibitor, is more effective than clomiphene for treatment of infertility in women with PCOS.  2. There was no significant difference in number of congenital abnormalities.  Evidence Rating Level: 1 (Excellent) Study Rundown: Polycystic ovarian syndrome (PCOS) is a common cause of infertility in women. It is a condition...
Image: PD 1. Women with PCOS were more likely to have a preterm delivery. 2. Among women with PCOS, those who exhibited hyperandrogenism were more likely to experience preeclampsia and preterm delivery. Evidence Rating Level: 2 (Good) Study Rundown: This study found that polycystic ovarian syndrome (PCOS) was associated with adverse...
Image: PD   Human Ovarian Follicle 1. HbA1c and fasting plasma glucose (FPG) demonstrated low sensitivity in detecting pre-diabetes in polycystic ovary syndrome (PCOS) patients. 2. The incidence of pre-diabetes was surprisingly high (7%) in normal weight PCOS patients (BMI < 25 kg/m2). Evidence Rating Level: 2 (Good) Study Rundown: This study found...