Tag: prednisone

1. For the treatment of ANCA-associated vasculitis, avacopan was non-inferior to prednisone taper for the number of remissions at week 26. 2. Avacopan was superior to prednisone taper for sustained remission at week 52. Evidence Rating Level: 1 (Excellent) Study Rundown: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a life-threatening vasculitis. The current...
1. The addition of tocilizumab, a monoclonal antibody against interleukin-6 (IL-6), to a glucocorticoid taper sustained remission in patients with giant-cell arteritis (GCA) through one year more effectively than glucocorticoids alone. 2. The addition of tocilizumab reduced the cumulative prednisone dose given over the trial period and the incidence of...
1. The addition of lenalidomide to standard R-CHOP chemotherapy reduced the negative prognostic impact of non-GCB phenotype in diffuse large B-cell lymphoma (DLBCL) progression-free and overall survival. Evidence Rating Level: 1 (Excellent)  Study Rundown: Therapy for diffuse large B-cell lymphoma (DLBCL) has advanced in recent years with the introduction of dose-intensified...
Image: PD 1. Adding angiogenesis-targeted sunitinib therapy to prednisone in the treatment of metastatic castration-resistant prostate cancer (mCRPC) does significantly improves progression-free survival, but not overall survival. 2. The potential uses of anti-angiogenic therapy in this setting requires further investigation. Evidence rating level: 1 (Excellent) Study Rundown: The standard approach to managing metastatic,...