Tag: pregnancy

1. Dolutegravir-based antiretroviral therapy regimens effectively suppressed maternal viral load during pregnancy, supporting their use to prevent vertical transmission. 2. Dolutegravir, emtricitabine, and tenofovir alafenamide fumarate carried relatively low risk of adverse fetal outcomes. Evidence Rating Level: 1 (Excellent) Study Rundown: Initiation of antiretroviral therapy (ART) for pregnant women infected with HIV-1...
1. Systematic review of RCTs demonstrates reduced rate of early preterm birth (<34 weeks) for high-risk (previous spontaneous preterm birth, short cervix) singleton pregnancies with vaginal progesterone and intramuscular 17-hydroxyprogesterone caproate (17-OHPC). 2. Efficacy of vaginal progesterone and 17-OHPC may be more effective for women with short cervices.  Evidence Rating Level:...
1. No significant increase in spontaneous abortion, preterm birth, major structural defects, or small for gestational age rates were found in women receiving 9vHPV vaccine during pregnancy (within 19 weeks pregnant). 2. No significant differences were found in adverse birth outcomes when comparing vaccinations in women 22 weeks before last...
1. In Washington State, pregnant patients were found to be at a higher risk of SARS-CoV-2 infection. 2. Results were more pronounced if patients belonged to a non-white racial or ethnic group or received their care in a language other than English. Evidence Level Rating: 2 (Good) As the COVID-19 pandemic continues to...
1. Maternal chronic conditions (particularly autoimmune conditions) such as type 1 and 2 diabetes, rheumatoid arthritis, and migraines were associated with a higher risk of cerebral palsy in offspring. 2. There was a stronger association of cerebral palsy risk with maternal chronic conditions recorded at delivery, as compared to...
1. COVID-19 infection in late pregnancy was associated with adverse birth outcomes, such as cesarean section delivery and iatrogenic preterm birth. 2. Limited evidence was found for maternal-fetal vertical transmission of SARS-CoV-2. Evidence Rating Level: 3 (Average) Coronavirus disease 2019 (COVID-19) is an ongoing concern in the healthcare sector. However, little is...
1. The COVID-19 lockdown was associated with a significantly increased risk of preterm birth, institutional stillbirth and neonatal mortality in Nepal. 2. The overall number of institutional births were significantly reduced with national lockdown, with increased inequality noted across ethnicities. Evidence Rating Level: 2 (Good) Study Rundown: Modelling studies have estimated a...
1. Mothers with preterm deliveries have significantly different levels of metabolites among them compared to term mothers. 2. There are different levels of metabolites among mothers with spontaneous preterm deliveries and with medically-indicated spontaneous preterm deliveries with or without preeclampsia. Evidence Rating Level: 2 (Good) Mothers who have preterm deliveries (PTD) may...
1. A midwifery continuity of care model, involving maternal care before, during, and after birth, yielded no improved clinical outcomes compared to a standard model of care. Evidence Rating Level: 1 (Excellent) Around the world, 10% of infants are born preterm and over 1 million die from preterm birth (PTB) complications...
1. Many first-line agents for depression and anxiety – including specific SSRIs, bupropion, and especially venlafaxine – were associated with an increased risk of birth defects if used during early pregnancy. Evidence Level Rating: 2 (Good) The management of depression and anxiety during pregnancy is challenging, especially considering that they affect...