Tag: pulmonary arterial hypertension

Image: CC 1. Macitentan, a derivative of the endothelin receptor antagonist bosentan, reduced morbidity from pulmonary arterial hypertension compared to placebo.    Evidence Rating Level: 1 (Excellent)  Study Rundown: Medical therapies for pulmonary arterial hypertension (PAH) generally work by reducing the pressure in the pulmonary vasculature. Endothelin receptor antagonists accomplish this by...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Riociguat for the Treatment of Pulmonary Arterial Hypertension In this phase III, double-blinded randomized control trial, investigators randomized patients with pulmonary arterial hypertension (n = 443) to riociguat, a guanylate...
Image: PD 1. A new link has been found between KCNK3 gene mutations and pulmonary arterial hypertension. 2. The mutations identified affect the ability of the KCNK3 ion channel to conduct current.  3. A drug known to stimulate KCNK3 channels can restore conductivity of some of the mutant channels in vitro.  Study Rundown:...