• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Macitentan better than placebo for preventing progression of pulmonary arterial hypertension [SERAPHIN Trial]

byTomi Jun
February 14, 2014
in Chronic Disease, Pulmonology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: CC

1. Macitentan, a derivative of the endothelin receptor antagonist bosentan, reduced morbidity from pulmonary arterial hypertension compared to placebo.   

Evidence Rating Level: 1 (Excellent) 

Study Rundown: Medical therapies for pulmonary arterial hypertension (PAH) generally work by reducing the pressure in the pulmonary vasculature. Endothelin receptor antagonists accomplish this by causing relaxation of the pulmonary vessels. Bosentan, licensed by Actelion Pharmaceuticals, is one of the main endothelin receptor antagonists on the market at present.

In this study (sponsored by Actelion), the bosentan derivative macitentan was compared to placebo for treatment of PAH. Macitentan was designed to be more efficacious and have a better safety profile than bosentan, but this study does not compare the two drugs directly.

Unlike other trials of PAH therapies which focus on exercise capacity as the primary end point, this trial used a composite endpoint of death and progression of PAH requiring additional treatment. Macitentan was found to reduce the risk of worsening PAH compared to placebo. A higher dose of macitentan was associated with a greater reduction in risk.

RELATED REPORTS

Sotatercept reduces adverse event risk in high-risk pulmonary arterial hypertension

#VisualAbstract: Sotatercept Improves Outcomes in Patients with Pulmonary Arterial Hypertension at High Risk for Death

Merck’s Winrevair: Pulmonary arterial hypertension drug shows success ahead of schedule

Click to read the study, published today in NEJM

Relevant Reading: The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N’-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist

In-Depth [randomized controlled trial]: This trial, known as SERAPHIN, randomized 742 PAH patients into 3 groups: placebo, 3mg macitentan once daily, 10mg macitentan once daily. Patients with a variety of etiologies of PAH were enrolled, including idiopathic, heritable and drug-related etiologies. The most common PAH etiology in the study was “idiopathic” followed by “associated with connective-tissue disease”. The mean duration of treatment was approximately 96 weeks.

The primary end point was time from treatment to a PAH-related event, including initiation of further medical or surgical treatment, or death from any cause. However, the number of deaths was low and the trial was not powered to show an effect on mortality alone. As such, although macitentan reduced the rate of the composite endpoint, this was primarily driven by reducing the rate of PAH-related morbidity, not mortality. The hazard ratio of 3mg macitentan vs. placebo was 0.67 (97.5% CI, 0.46 to 0.97; P=0.01). The hazard ratio of 10mg macitentan vs. placebo was 0.50 (97.5% CI, 0.34 to 0.75; P<0.001).

Macitentan was associated with a similar incidence of adverse events as placebo, though nasopharyngitis, anemia and headaches were more common in the macitentan groups than the placebo group. Anemia has been reported in conjunction with other endothelin receptor antagonists.

More from this author: Early risk factor for progression of cystic fibrosis identified, Gut microbes implicated in stroke and heart attacks: new dietary link, New leukemia mutation offers therapeutic targets, Childhood ADHD associated with increased risk of suicide, A marker of aggressive liver cancer and potential therapeutic target identified

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. 

Tags: pulmonary arterial hypertension
Previous Post

Fluconazole in first trimester not associated with increase in most birth defects

Next Post

Rituximab linked with reduced chronic immune disease following stem cell transplantation

RelatedReports

Multiple-electrode switching radiofrequency ablation may successfully treat lung tumors
Cardiology

Sotatercept reduces adverse event risk in high-risk pulmonary arterial hypertension

June 5, 2025
#VisualAbstract: Sotatercept Improves Outcomes in Patients with Pulmonary Arterial Hypertension at High Risk for Death
StudyGraphics

#VisualAbstract: Sotatercept Improves Outcomes in Patients with Pulmonary Arterial Hypertension at High Risk for Death

April 17, 2025
Pulmonary MRI with ultrashort echo time is comparable to pulmonary CT
Pharma

Merck’s Winrevair: Pulmonary arterial hypertension drug shows success ahead of schedule

March 25, 2025
Multiple-electrode switching radiofrequency ablation may successfully treat lung tumors
Cardiology

Sotatercept improves outcomes in patients with pulmonary arterial hypertension

May 2, 2023
Next Post
Rituximab linked with reduced chronic immune disease following stem cell transplantation

Rituximab linked with reduced chronic immune disease following stem cell transplantation

Certain cancer therapy innovations not associated with decreasing mortality

Certain cancer therapy innovations not associated with decreasing mortality

Smokeless tobacco use in children has not changed

Racial backgrounds key to shaping the face of smoking-related mortality in South Africa

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Tirzepatide-associated improvements in cardiometabolic risk factors linked to degree of weight loss
  • Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy
  • 2 Minute Medicine Rewind June 23, 2025
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.