Tag: renal failure
1. A significantly greater proportion of patients in the voclosporin group achieved complete renal responses after 52 weeks compared to the placebo group.
2. The safety profile between the voclosporin group and placebo group were comparable with 21% of patients in both groups experiencing serious adverse events.
Evidence Rating Level: 1...
1. The median number of RRT-free days was 12 days (IQR 0-25) in the delayed strategy and 10 days (IQR 0-24) in the more-delayed strategy.
2. Hazard ratio for mortality at day 60 was 1.65 in the more-delayed strategy.
Evidence Rating Level: 1 (Excellent)
Study Rundown: Uncertainty exists regarding the duration for...
1. Oxygenated hypothermic machine perfusion (HMPO2) of kidneys donated after circulatory death was associated with fewer severe complications and lower rates of graft failure compared to hypothermic machine perfusion without oxygenation (HMP).
2. There was no significant difference in mean eGFR between HMPO2 and HMP despite potential beneficial effects suggested...
1. In this retrospective quality improvement cohort study from the United States, a multidisciplinary approach was linked with increased rates of peritoneal dialysis initiation compared with national averages
Evidence Rating Level: 2 (Good)
Study Rundown: Chronic kidney disease is one of the most prevalent chronic diseases in North America, with enormous...
1. In this retrospective cohort study from Israel, hypertension at the age of 16-19 years old was linked with later-life end stage renal disease (ESRD).
2. The association between adolescent hypertension and ESRD remained after accounting for co-morbid conditions such as obesity, and after excluding those with severe hypertension.
Evidence Rating...
1. Veterans receiving pre-end stage renal disease (ESRD) nephrology care in under the Medicare system were more likely to undergo dialysis and had a higher two-year mortality rate than veterans that received pre-ESRD care through the Department of Veteran’s Affairs (VA).
2. Differences in dialysis initiation between Medicare and VA...
1. Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients.
2. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission.
Evidence Rating...
1. Adults with chronic kidney disease (CKD) and heart failure with reduced LVEF who received implantable cardioverter defibrillators (ICDs) did not differ from matched non-ICD patients with relation to all-cause mortality.
2. However, ICD placement in patients with CKD was associated with increased risk of heart failure-related and any-cause hospitalization.
Evidence...
1. Living kidney donation was associated with higher diastolic blood pressure, lower estimated glomerular filtration rates, and increased relative risk of preeclampsia and end-stage renal disease (ESRD).
2. Data did not show that donors have a higher risk for type 2 diabetes, hypertension, cardiovascular disease, negative psychosocial health outcomes, reduced...
1. Patients with end-stage renal disease (ESRD) have significantly worse survival outcomes following left ventricular assist device (LVAD) implantation compared to recipients without ESRD.
2. The median time to death was substantially shorter in those with ESRD, with many patients dying during the index hospitalization.
Evidence Rating Level: 2 (Good)
Study Rundown:...