Tag: renal transplant

There are many reasons why a patient may be made inactive on the kidney transplant waiting list, including psychosocial or financial issues or medical comorbidities. This has important implications for a patient’s overall morbidity and mortality. Sensitization, as measured by calculated plasma reactive antibodies (cPRA), also affects likelihood of...
Association of Racial Disparities With Access to Kidney Transplant After the Implementation of the New Kidney Allocation System There are many reasons why a patient may be made inactive on the kidney transplant waiting list, including psychosocial or financial issues or medical comorbidities. This has important implications for a patient’s...
1. For patients with Lupus nephritis end stage renal disease (LN ESRD), renal transplant reduced the risk of death by about 70%. 2. The risk reduction was driven primarily by decreased risk of death from cardiovascular disease and infection. Evidence Rating Level: 2 (Good) Study Rundown: Lupus nephritis (LN) is a common...
1. No HCV infection was detected in patients receiving HCV-infected kidneys 12 weeks following treatment. 2. No antiviral treatment-related complications occurred recipients of HCV-infected kidneys. Evidence Rating Level: 2 (Good) Study Rundown: Kidney failure and end-stage kidney disease result in significant morbidity and mortality. While kidney transplant is a viable solution for...
1. Ledipasvir-sofosbuvir treatment was associated with rapid chronic hepatitis C (HCV) RNA suppression. 2. Ledipasvir-sofosbuvir treatment was generally well tolerated in kidney transplant patients. Evidence Rating Level: 1 (Excellent) Study Rundown: Infection with chronic HCV virus is very common within kidney transplant recipients. About 10% of recipients in Western countries will be...
1. Antiphospholipid syndrome (APLS) in an autoimmune condition causing mechanical endothelial injury leading to activation of a pathway that triggers vascular stenosis; this pathway is initiated by a kinase referred to as mammalian target of rapamycin (mTOR). 2. Inhibition of the mammalian target of rapamycin (mTOR) with sirolimus was...
Image: PD 1. Retransplant patients that experienced acute rejection, hospitalization, or delayed graft function after their first kidney transplant were more likely to experience such negative outcomes post-retransplant.  2. Relisting of patients was found to be statistically dependent on outcomes within the first year of the primary transplant, including GFR and...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Cancer Screening Study: randomized screening trial The use of mammography in breast cancer screening has...