Tag: schizophrenia

1. Xanomeline-trospium treatment showed a greater reduction in the degree of psychosis in patients with schizophrenia compared to placebo. 2. Patients treated with xanomeline-trospium experienced adverse events such as constipation and nausea but no increase in the incidence of extrapyramidal symptoms. Evidence Rating Level: 1 (Excellent) Study Rundown: Current medications, primarily dopamine-antagonists,...

1. Environmental liability for schizophrenia moderated the association of stressful life events with mental and physical health. Evidence Rating Level: 2 (Good) Schizophrenia research has elucidated the roles of environmental and genetic liability as well as stressful life events (SLEs) in schizophrenia pathogenesis. However, few studies have illustrated the interactions of...

Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors 1. Hyperthyroidism was associated with a higher rate of breast cancer among women. 2. Risk was particularly elevated for those with toxic nodular goiter. Evidence Rating Level: 2 (Good) Breast cancer is the most common cancer among women across the...

1. An oral compound, SEP-363856 was shown to significantly reduce the total score of the Positive and Negative Symptom Scale (PANSS) from baseline compare to placebo for patients with an acute exacerbation of schizophrenia. 2. One patient treated with SEP-363856 had sudden cardiac death but had history of coronary artery...

1. In this study of 3-dimensional cerebral organoids of schizophrenia patients and healthy controls, differences were found in mitochrondrial function, response to stimulation and depolarization, ATP production, and overall pathway and neuronal generation deficits. Evidence Rating Level: 3 (Average) Patient-derived induced pluripotent stem cells (iPSCs) come from somatic cells through cellular reprogramming...

1. Cross-generational transmission between bipolar disorder and schizophrenia was predominantly based on genetics, while transmission between bipolar disorder and major depression was equally influenced by genetics and child-rearing practices. Evidence Rating Level: 2 (Good) Cross-generational transmission of bipolar disorder is less well-known, with specific gaps related to whether parental bipolar disorder...

Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life 1. Greater variability in visit-to-visit systolic and diastolic blood pressure readings in early adulthood is associated with adverse myocardial structure changes and impaired systolic and diastolic function. Evidence Rating: 2 (Good) Blood pressure (BP) control...

Estimation of Glomerular Filtration Rate With vs Without Including Patient Race 1. The exclusion of patient race from glomerular filtration rate (GFR) estimation resulted in systematic error that significantly underestimated GFR in African American individuals more so than non-African Americans. Evidence Rating Level: 2 (Good) Glomerular filtration rate (GFR), an integral component...

1. Parental income mobility may be inversely associated with the risk of developing schizophrenia later in life Evidence Rating Level: 2 (Good) There are clear associations between a number of mental health conditions and socioeconomic status. The link between parental socioeconomic position (SEP) and schizophrenia risk amongst offspring, however, has...

PD-1 blockade in advanced adrenocortical carcinoma 1. Pembrolizumab may provide clinically meaningful anti-tumor activity in the setting of adrenocortical carcinoma, particularly in tumors characterized by microsatellite instability and/or mismatch repair  Evidence Rating Level: 2 (Good) Adrenocortical carcinomas (ACC) are rare and typically carry a poor prognosis, with the majority of patients presenting...