Tag: sepsis

1. In this randomized controlled trial, hemoperfusion with polymyxin B resulted in similar 28-day mortality compared to sham hemoperfusion for patients with sepsis with elevated endotoxins. Evidence Rating Level: 1 (Excellent) Study Rundown: In sepsis, high endotoxin levels are associated with greater risk of multiple organ failure and mortality. Though numerous...
1. Patients with septic shock in the intensive care unit (ICU) undergoing mechanical ventilation and managed with adjunctive continuous hydrocortisone infusion, did not have a lower 90-day mortality compared to placebo. 2. There was no difference between the placebo and hydrocortisone groups in secondary outcomes of mortality at 28 days,...
1. No moderate- or high-level evidence was found that SEP-1 or its hemodynamic interventions increase survival in septic adults. 2. The authors suggest that the CMS should evaluate its approval process to ascertain how interventions that are deficient in evidence were adopted and how improvements can be made to this...
1. For predicting short-term mortality in patients with suspected infection, quick Sequential Organ Failure Assessment (qSOFA) had moderate specificity and poor sensitivity. 2. The systemic inflammatory response syndrome (SIRS) criteria were poorly specific but more sensitive than qSOFA, which supports the use of the SIRS criteria as a screening tool...
1. Increased education and process standardization led to a significant decrease in time to antibiotic administration among inpatient bone marrow transplant (BMT) pediatric patients with a new fever. 2. Proportion of BMT patients who received antibiotics within 60 minutes of first fever more than doubled after QI interventions were implemented. Study...
1. Increasing provider education and streamlining antibiotic order sets led to significantly decreased time to antibiotic administration in children with intestinal failure (IF) and fever in a quaternary pediatric emergency department (ED). 2. No significant difference was found in rates of mortality, hypoglycemia, or intensive care unit (ICU) and hospital...
1. No significant difference was observed in 28-day mean SOFA score or overall mortality in patients who received levosimendan vs. controls. 2. A significant increase in successful weaning from mechanical ventilation was observed in controls vs. patients who received levosimendan. Evidence Rating Level: 1 (Excellent)  Study Rundown: Septic shock is a state...
1. Compared to standard care, 6 months of primary care interventions were not associated with any improvement in mental health-related quality of life (QoL) among survivors of sepsis. 2. At 6 months of follow up, patients receiving primary care interventions reported improved physical functioning and an increased ability to perform...
1. Patients with sepsis were predisposed to ICU-acquisition of further infections. 2. Sepsis is associated with a degree of immunosuppression. Evidence Rating Level: 2 (Good)        Study Rundown: Sepsis is one of the leading causes of death in hospitalized patients, and has been associated with an increased risk of secondary...
1. Sepsis, now defined as “life threatening organ dysfunction caused by a dysregulated host response to infection,” can be identified by a change of 2 or more points in a patient’s Sequential Organ Failure Assessment (SOFA) score. 2. Among patients with a suspected infection, the quick SOFA (qSOFA) score can...