Tag: sepsis

1. Retrospective analysis of hospital records showed decreased hospital admission rates for non-COVID-19 diseases in Denmark since the first lockdown. 2. Mortality rates were also shown to be higher for non-COVID-19 diseases, including respiratory diseases, cancer, pneumonia, and sepsis. Evidence Rating Level: 2 (Good) Study Rundown: The COVID-19 pandemic has put a...

1. This external validation study suggests that the Epic Sepsis Model, a proprietary sepsis prediction algorithm, was a poor predictor of sepsis in hospitalized patients, with poor sensitivity, discrimination, and calibration in predicting the onset of sepsis. 2. The widespread implementation of the Epic Sepsis Model despite its poor clinical...

1. Black patients demonstrated lower in-hospital mortality than White patients with equivalent Sequential Organ Failure Assessment (SOFA) scores. 2. This overestimatation of Black patient mortality might lead to deprioritization of this population during public health crises based on the current Crisis Standards of Care guidelines. Evidence Rating Level: 2 (Good) Study Rundown:...

1. There was no association found between positive fluid balance at the time of discharge and readmission at 30 days post-discharge in non-critically ill patients hospitalized for sepsis. Evidence Rating Level: 2 (Good) Study Rundown: Evidence suggests that the administration of intravenous fluids in patients hospitalized for sepsis is associated with...

Click to read the study in The Lancet Oncology.

1. Adoption of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) program resulted in greater adherence to individual process measures such as lactate measurement, early antibiotics, and fluid therapy. 2. These increases were variable in magnitude and did not associate with meaningful changes in sepsis outcomes. Evidence Rating Level:...

1. Treatment with dexmedetomidine was shown not to differ from propofol treatment in adult patients with sepsis who were under mechanical ventilation. 2. No significant difference was found in functional, quality-of-life, or cognitive assessment scores between the two treatment methods. Evidence Rating Level: 1 (Excellent) Study Rundown: Sedative medications are often administered...

1. The most common complications associated with COVID-19 with high absolute risk were viral pneumonia, respiratory failure, acute kidney failure, and sepsis. 2. Complications highly associated with COVID-19 with low absolute risk were myocarditis, pneumothorax, and disseminated intravascular coagulation. Evidence Rating Level: 2 (Good) During the COVID-19 pandemic, greater than 50 million individuals...

1. Delaying antibiotic treatment for UTI in older adults did not increase risk of bloodstream infection compared to immediate antibiotic treatment. 2. Delayed treatment may have contributed to increased risk of mortality in this group. Evidence Rating Level: 3 (Average) Urinary tract infection (UTIs) is one of the most common reasons for...

1. Patients experienced a greater incidence of severe adverse events during the 3-month period following prescription of a steroid burst compared to the 3-month period prior. 2. During the posttreatment period, the risk for severe adverse events generally appeared to decrease over time but nonetheless remained elevated above baseline. Evidence Rating...