Tag: sepsis

1. Patients experienced a greater incidence of severe adverse events during the 3-month period following prescription of a steroid burst compared to the 3-month period prior. 2. During the posttreatment period, the risk for severe adverse events generally appeared to decrease over time but nonetheless remained elevated above baseline. Evidence Rating...
1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic treatment and lactate levels were associated with improved outcomes in this population. Evidence Rating Level: 2 (Good) Sepsis bundles, or protocols...
Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis 1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic...
1. In this randomized clinical trial, intravenous infusion of high-dose vitamin C vs placebo for 96 hours resulted in no significant differences in the modified Sequential Organ Failure Assessment score at 96 hours or in levels of C-reactive protein and thrombomodulin at 168 hours. 2. There were three secondary outcomes...
1. In this randomized clinical trial, intravenous infusion of high-dose vitamin C vs placebo for 96 hours resulted in no significant differences in the modified Sequential Organ Failure Assessment score at 96 hours or in levels of C-reactive protein and thrombomodulin at 168 hours. 2. There were three secondary outcomes...
1. In this prospective multicenter observational trial among adult patients with severe manifestations of sepsis, administration of antimicrobial treatment prior to collection of blood cultures resulted in significantly diminished sensitivity (52.9%). 2. Study findings demonstrated the importance of obtaining blood cultures prior to proceeding with antimicrobial therapy, strengthening the current...
The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial 1. Selective serotonin reuptake inhibitors (SSRIs) are not associated with significant short-term reductions in depressive symptoms in the primary care setting, but reduce short-term anxiety and improve...
1. In this prospective multicenter observational trial among adult patients with severe manifestations of sepsis, administration of antimicrobial treatment prior to collection of blood cultures resulted in significantly diminished sensitivity (52.9%). 2. Study findings demonstrated the importance of obtaining blood cultures prior to proceeding with antimicrobial therapy, strengthening the current...
1. Among patients with septic shock and acute kidney injury (AKI), there was no significant difference in 90-day mortality between early (within 12 hours) and delayed (after 48 hours) initiation of renal-replacement therapy (RRT). 2. Patients in the delayed group had significantly more days free from RRT, with no significant...
The rates of Group B Streptococcal (GBS) bacteremia recurrence in infants with an initial course of late-onset infection who received shortened and prolonged IV antibiotic therapy were 1.8% and 2.3%, respectively. There was no significant difference in the adjusted absolute difference between these 2 rates. Evidence Rating Level: 2...