Tag: sepsis
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1. Quality improvement (QI) methodology improved adherence to national pediatric sepsis guidelines and was sustained during the study period.
2. After the QI intervention was implemented, there was an increase in cases of pediatric severe sepsis or septic shock between patient deaths from sepsis.
Evidence Rating Level: 1 (Excellent)
Study Rundown:...
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1. Patients with a Sepsis in Obstetrics Score (SOS) ≥6 were more likely to be admitted to the ICU.
2. The SOS predicted risk of severe sepsis-related morbidity more accurately than other existing ED sepsis scoring systems.
Evidence Rating Level: 2 (Good)
Study Rundown: This study found that the SOS,...
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1. A new evaluation algorithm for early-onset sepsis in neonates ≥ 34 weeks gestation incorporates both maternal and newborn clinical factors to stratify into 3 groups – treat empirically, observe and evaluate, and continued observation.
2. Usage of this algorithm may decrease antibiotic treatment for 80 000 to 240...
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1. Previous phase I and phase II trials in severe sepsis patients show the lipopolysaccharide antagonist eritoran decreases mortality.
2. In this phase III trial, eritoran is not shown to decrease 28-day or 1-year mortality in severe sepsis and septic shock patients.
Sepsis is the result of abnormal systemic...
1. Early goal-directed therapy in patients with severe sepsis and septic shock prior to admission to the intensive care unit significantly reduced organ dysfunction and mortality rates compared to standard therapy to achieve parameters for hemodynamic support.
Original Date of Publication: November 8, 2001
Study Rundown: The systemic inflammatory response syndrome (SIRS)...