Tag: sepsis

Image: PD 1. Quality improvement (QI) methodology improved adherence to national pediatric sepsis guidelines and was sustained during the study period. 2. After the QI intervention was implemented, there was an increase in cases of pediatric severe sepsis or septic shock between patient deaths from sepsis. Evidence Rating Level: 1 (Excellent) Study Rundown:...
Image: PD  1. Patients with a Sepsis in Obstetrics Score (SOS) ≥6 were more likely to be admitted to the ICU.  2. The SOS predicted risk of severe sepsis-related morbidity more accurately than other existing ED sepsis scoring systems.    Evidence Rating Level: 2 (Good) Study Rundown: This study found that the SOS,...
Image: PD 1. A new evaluation algorithm for early-onset sepsis in neonates ≥ 34 weeks gestation incorporates both maternal and newborn clinical factors to stratify into 3 groups – treat empirically, observe and evaluate, and continued observation. 2. Usage of this algorithm may decrease antibiotic treatment for 80 000 to 240...
Image: PD 1. There was no significant difference in mortality between patients with septic shock receiving low-dose hydrocortisone compared to placebo 2. Hydrocortisone therapy reversed shock more quickly, but resulted in more cases of superinfection Original Date of Publication: January 10, 2008 Study Rundown: Recommendations that patients with septic shock be treated with low-dose...
Image: PD 1. Previous phase I and phase II trials in severe sepsis patients show the lipopolysaccharide antagonist eritoran decreases mortality.   2. In this phase III trial, eritoran is not shown to decrease 28-day or 1-year mortality in severe sepsis and septic shock patients. Sepsis is the result of abnormal systemic...
Classics Series, Landmark Trials in Medicine
1. Early goal-directed therapy in patients with severe sepsis and septic shock prior to admission to the intensive care unit significantly reduced organ dysfunction and mortality rates compared to standard therapy to achieve parameters for hemodynamic support. Original Date of Publication: November 8, 2001 Study Rundown: The systemic inflammatory response syndrome (SIRS)...