Tag: septic shock

Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. High versus Low Blood-Pressure Target in Patients with Septic Shock While there are numerous recommendations for goal mean arterial pressure (MAP) during resuscitation of patients with septic shock, there is...
Image: PD 1. Quality improvement (QI) methodology improved adherence to national pediatric sepsis guidelines and was sustained during the study period. 2. After the QI intervention was implemented, there was an increase in cases of pediatric severe sepsis or septic shock between patient deaths from sepsis. Evidence Rating Level: 1 (Excellent) Study Rundown:...
Image: PD 1. Patients in septic shock who received esmolol achieved reductions in heart rate to target levels without an associated increase in adverse events. 2. The 28-day mortality rate was 49.4% among patients receiving esmolol compared to 80.5% among patients receiving standard care (p<.001).  Evidence Rating Level: 1 (Excellent) Study Rundown: Septic...
Image: PD 1. There was no significant difference in mortality between patients with septic shock receiving low-dose hydrocortisone compared to placebo 2. Hydrocortisone therapy reversed shock more quickly, but resulted in more cases of superinfection Original Date of Publication: January 10, 2008 Study Rundown: Recommendations that patients with septic shock be treated with low-dose...
Classics Series, Landmark Trials in Medicine
1. Early goal-directed therapy in patients with severe sepsis and septic shock prior to admission to the intensive care unit significantly reduced organ dysfunction and mortality rates compared to standard therapy to achieve parameters for hemodynamic support. Original Date of Publication: November 8, 2001 Study Rundown: The systemic inflammatory response syndrome (SIRS)...